Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels
Xiao Wang,Carlos T. Moraes +1 more
TLDR
By increasing the efficiency of the mitochondrial oxidative phosphorylation system, cancer progression is hampered by decreases in cell proliferation and invasiveness.About:
This article is published in Molecular Oncology.The article was published on 2011-10-01 and is currently open access. It has received 65 citations till now. The article focuses on the topics: Mitochondrial biogenesis & Mitochondrion.read more
Citations
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Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
Rizwan Haq,Jonathan Shoag,Pedro Andreu-Perez,Satoru Yokoyama,Satoru Yokoyama,Hannah E. Edelman,Glenn C. Rowe,Dennie T. Frederick,Aeron D. Hurley,Abhinav Nellore,Andrew L. Kung,Jennifer A. Wargo,Jun S. Song,David E. Fisher,Zolt Arany,Hans R. Widlund +15 more
TL;DR: It is shown that BRAF inhibition also induces an oxidative phosphorylation gene program, mitochondrial biogenesis, and the increased expression of the mitochondrial master regulator, PGC1α, and a target of BRAF, the melanocyte lineage factor MITF, directly regulates the expression of P GC1α.
Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells
Matthew G. Vander Heiden,Matthew G. Vander Heiden,Jason W. Locasale,Jason W. Locasale,Kenneth D. Swanson,Hadar Sharfi,Gregory J. Heffron,Daniel Amador-Noguez,Heather R. Christofk,Gerhard Wagner,Joshua D. Rabinowitz,John M. Asara,Lewis C. Cantley,Lewis C. Cantley +13 more
TL;DR: In this paper, the authors demonstrate that phosphoenolpyruvate (PEP) can act as a phosphate donor in mammalian cells because PEP participates in the phosphorylation of the glycolytic enzyme phosphoglycerate mutase (PGAM1) in PKM2-expressing cells.
Journal ArticleDOI
After the banquet: Mitochondrial biogenesis, mitophagy, and cell survival
TL;DR: It is concluded that in primary neurons and other mitochondrially dependent cells, disruptions in any phase of the mitochondrial recycling process can contribute to cellular dysfunction and disease.
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PGC-1α as a Pivotal Factor in Lipid and Metabolic Regulation.
TL;DR: It is demonstrated that PGC-1α plays a central role in coordinating the gene expression of key components of mitochondrial biogenesis and as a critical metabolic regulator in many vital organs, including white and brown adipose tissue, skeletal muscle, heart, liver, and kidney.
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MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases
Masami Hashimoto,Sandra R. Bacman,Susana Peralta,Marni J. Falk,Anne Chomyn,David C. Chan,Sion L. Williams,Carlos T. Moraes +7 more
TL;DR: Short versions of the mitoTALEN specific for the MERRF m.8344A>G mutation are designed, which will improve the ability to package these large sequences into viral vectors, bringing the use of these genetic tools closer to clinical trials.
References
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Why do cancers have high aerobic glycolysis
TL;DR: In this article, the authors propose that persistent metabolism of glucose to lactate even in aerobic conditions is an adaptation to intermittent hypoxia in pre-malignant lesions, which leads to microenvironmental acidosis requiring evolution to phenotypes resistant to acid-induced cell toxicity.
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The metabolism of tumors in the body.
TL;DR: The question of whether tumor cells in living animals can be killed off through lack of energy, and the related question of how the tumors are supplied with oxygen and glucose in the body are discussed.
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Sulforhodamine B colorimetric assay for cytotoxicity screening
TL;DR: The sulforhodamine B (SRB) assay is used for cell density determination, based on the measurement of cellular protein content, which is an efficient and highly cost-effective method for screening.
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Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators
Julie St-Pierre,Stavit Drori,Marc Uldry,Jessica M. Silvaggi,James Rhee,Sibylle Jäger,Christoph Handschin,Kangni Zheng,Jiandie D. Lin,Wenli Yang,David Simon,Robert M. Bachoo,Robert M. Bachoo,Bruce M. Spiegelman +13 more
TL;DR: Increase in PGC-1alpha levels dramatically protects neural cells in culture from oxidative-stressor-mediated death, providing a potential target for the therapeutic manipulation of these important endogenous toxins.
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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
Mary A. Selak,Sean M. Armour,Elaine D. MacKenzie,Houda Boulahbel,David G. Watson,Kyle D. Mansfield,Yi Pan,M. Celeste Simon,Craig B. Thompson,Eyal Gottlieb +9 more
TL;DR: A mitochondrion-to-cytosol signaling pathway that links mitochondrial dysfunction to oncogenic events is described, suggesting a mechanistic link between SDH mutations and HIF-1alpha induction, providing an explanation for the highly vascular tumors that develop in the absence of VHL mutations.