Open AccessDOI
Inflammation and pain in skin and deep tissues
TLDR
Evaluate the change in sensitivity after inflammation inside and outside the irradiated skin and investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.Abstract:
Ultraviolet-B irradiation model has been used for many years as a translational model since it is well known to induce cutaneous inflammatory pain in both animals and humans. The aim of this study project was to evaluate time course and sensory changes induced by UVB and in particular: 1) evaluate the change in sensitivity after inflammation inside and outside the irradiated skin, 2) investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia, 3) investigate the effect on mechanical hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.read more
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Book Chapter
Wall and Melzack's textbook of pain
TL;DR: The Wall and Melzack's Textbook of Pain is revised under new editorial leadership, and with a host of new, multidisciplinary international contributors.
Journal ArticleDOI
Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo
TL;DR: Findings point towards a regulatory function for nerve growth factor in vivo in the stimulation of sensory neuropeptide synthesis during prolonged inflammatory processes.
Journal ArticleDOI
Sensory defunctionalization induced by 8% topical capsaicin treatment in a model of ultraviolet-B-induced cutaneous hyperalgesia.
TL;DR: In this article, the authors explored the contribution of capsaicin-sensitive nociceptors in the development of mechanical and heat hyperalgesia in humans following ultraviolet-B (UVB) irradiation.
References
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Journal ArticleDOI
Modality-specific nociceptor sensitization following UV-B irradiation of human skin.
TL;DR: Local inflammation by UV-B irradiation sensitizes not only sensory endings, but also axons, which could contribute to inflammatory hyperalgesia by facilitating spike generation and increasing peak discharge frequencies of nociceptors.
Journal ArticleDOI
Central origin of pinprick hyperalgesia adjacent to an UV-B induced inflammatory skin pain model in healthy volunteers
TL;DR: Evidence is provided that the development of mechanical hyperalgesia surrounding an experimental sunburn was not influenced by continuous peripheral afferent blockade with local anaesthetic at 8h after UV-B irradiation, and the hypothesis that in theUV-B model peripheral nociceptive afferent input of inflamed skin may enhance central hypersensitivity of mechanosensitive nocICEptors in a larger receptive field far beyond the inflamedskin is supported.
Journal ArticleDOI
Objective validation of central sensitization in the rat UVB and heat rekindling model
TL;DR: Face, construct and predictive validity are key requisites of animal models; electromyogram recordings were utilized to objectively demonstrate validity of the rat UVB/HR model.
Validation of infrared thermography in serotonin-induced itch model in rats
TL;DR: In this article, the authors validated the application of infrared thermography in a serotonin-induced itch model in rats since the only available method in animal models of itch is the count of scratching bouts.