Open AccessDOI
Inflammation and pain in skin and deep tissues
TLDR
Evaluate the change in sensitivity after inflammation inside and outside the irradiated skin and investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.Abstract:
Ultraviolet-B irradiation model has been used for many years as a translational model since it is well known to induce cutaneous inflammatory pain in both animals and humans. The aim of this study project was to evaluate time course and sensory changes induced by UVB and in particular: 1) evaluate the change in sensitivity after inflammation inside and outside the irradiated skin, 2) investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia, 3) investigate the effect on mechanical hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.read more
Citations
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Book Chapter
Wall and Melzack's textbook of pain
TL;DR: The Wall and Melzack's Textbook of Pain is revised under new editorial leadership, and with a host of new, multidisciplinary international contributors.
Journal ArticleDOI
Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo
TL;DR: Findings point towards a regulatory function for nerve growth factor in vivo in the stimulation of sensory neuropeptide synthesis during prolonged inflammatory processes.
Journal ArticleDOI
Sensory defunctionalization induced by 8% topical capsaicin treatment in a model of ultraviolet-B-induced cutaneous hyperalgesia.
TL;DR: In this article, the authors explored the contribution of capsaicin-sensitive nociceptors in the development of mechanical and heat hyperalgesia in humans following ultraviolet-B (UVB) irradiation.
References
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Journal ArticleDOI
Repeated intramuscular injections of nerve growth factor induced progressive muscle hyperalgesia, facilitated temporal summation, and expanded pain areas.
TL;DR: The daily injections of NGF produced a progressive manifestation of muscle soreness, mechanical hyperalgesia, temporal summation of pressure pain, and pressure‐induced pain distribution, illustrating that the prolonged NGF application affects peripheral and central mechanisms and may reflect process in musculoskeletal pain conditions.
Journal ArticleDOI
Rofecoxib attenuates both primary and secondary inflammatory hyperalgesia: a randomized, double blinded, placebo controlled crossover trial in the UV-B pain model.
Thomas Sycha,Sebastian Anzenhofer,Stephan Lehr,Leopold Schmetterer,Boris A. Chizh,Hans-Georg Eichler,Burkhard Gustorff +6 more
TL;DR: Peripheral effects of rofecoxib in a human inflammatory UV‐B pain model is confirmed and circumstantial evidence that even a standard clinical dose of roFecoxIB reduces central hyperalgesia in inflammatory pain is provided.
Journal ArticleDOI
Enhanced temporal summation of pressure pain in the trapezius muscle after delayed onset muscle soreness
TL;DR: In this article, the authors evaluated changes in temporal summation of pressure pain after induction of delayed onset muscle soreness (DOMS) of the trapezius muscle using a computer-controlled algometer.
Journal ArticleDOI
Pressure-induced muscle pain and tissue biomechanics: a computational and experimental study
Sara Finocchietti,Mogens Nielsen,Carsten Dahl Mørch,Lars Arendt-Nielsen,Thomas Graven-Nielsen +4 more
TL;DR: The results suggest that pressure‐induced muscle pain is mainly related to muscle strain and most efficiently induced by large rounded probes, while smaller and flat ones mainly activate superficial structures.
Journal ArticleDOI
Pressure pain threshold mapping of the trapezius muscle reveals heterogeneity in the distribution of muscular hyperalgesia after eccentric exercise.
TL;DR: The present results showed the topographical distribution of pressure pain sensitivity over the trapezius muscle and also that hyperalgesia developed in a heterogeneous manner in response to eccentric exercise underlining sensory partitioning of the muscle.