Open AccessDOI
Inflammation and pain in skin and deep tissues
TLDR
Evaluate the change in sensitivity after inflammation inside and outside the irradiated skin and investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.Abstract:
Ultraviolet-B irradiation model has been used for many years as a translational model since it is well known to induce cutaneous inflammatory pain in both animals and humans. The aim of this study project was to evaluate time course and sensory changes induced by UVB and in particular: 1) evaluate the change in sensitivity after inflammation inside and outside the irradiated skin, 2) investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia, 3) investigate the effect on mechanical hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.read more
Citations
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Book Chapter
Wall and Melzack's textbook of pain
TL;DR: The Wall and Melzack's Textbook of Pain is revised under new editorial leadership, and with a host of new, multidisciplinary international contributors.
Journal ArticleDOI
Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo
TL;DR: Findings point towards a regulatory function for nerve growth factor in vivo in the stimulation of sensory neuropeptide synthesis during prolonged inflammatory processes.
Journal ArticleDOI
Sensory defunctionalization induced by 8% topical capsaicin treatment in a model of ultraviolet-B-induced cutaneous hyperalgesia.
TL;DR: In this article, the authors explored the contribution of capsaicin-sensitive nociceptors in the development of mechanical and heat hyperalgesia in humans following ultraviolet-B (UVB) irradiation.
References
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Journal ArticleDOI
Evoked pain measures in fibromyalgia
TL;DR: This chapter focuses on the evaluation of altered pain sensitivity in fibromyalgia, describes current measurement methodology, briefly reviews studies of sensitivity to experimentally evoked painful and non-painful sensations, analyses the factors assessed by different measurement methodologies, and concludes with recommendations for future diagnostic criteria and measurement methods.
Journal ArticleDOI
Secondary hyperalgesia to mechanical but not heat stimuli following a capsaicin injection in hairy skin.
TL;DR: No correlation existed between the magnitude of capsaicin evoked pain and the areas mechanical hyperalgesia to punctate and stroking stimuli or the area of flare, which suggests that independent mechanisms may mediate evokedPain, central sensitization that leads to mechanical hyperAlgesia, and axon reflexive flare.
Journal ArticleDOI
Inflammatory Models of Pain and Hyperalgesia.
Ke Ren,Ronald Dubner +1 more
TL;DR: This article addresses important pain research models in nonhuman animals that attempt to mimic human persistent pain conditions and provides analgesic agents whenever it does not interfere with the purpose of the experiment.
Journal ArticleDOI
Biological importance of the retrograde axonal transport of nerve growth factor in sensory neurons
TL;DR: It is shown that sensory ganglia from newborn and adult rats respond in nerve growth factor and that its retrograde axonal transport is biologically relevant, as indicated by an increase in substance P and in general protein content.
Journal ArticleDOI
Inflammatory pain: the cellular basis of heat hyperalgesia.
TL;DR: The signalling pathways believed to be involved in the potentiation of TRPV1 are described, and the current understanding of how inflammatory mediators couple to these pathways is described.