Open AccessDOI
Inflammation and pain in skin and deep tissues
TLDR
Evaluate the change in sensitivity after inflammation inside and outside the irradiated skin and investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.Abstract:
Ultraviolet-B irradiation model has been used for many years as a translational model since it is well known to induce cutaneous inflammatory pain in both animals and humans. The aim of this study project was to evaluate time course and sensory changes induced by UVB and in particular: 1) evaluate the change in sensitivity after inflammation inside and outside the irradiated skin, 2) investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia, 3) investigate the effect on mechanical hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.read more
Citations
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Book Chapter
Wall and Melzack's textbook of pain
TL;DR: The Wall and Melzack's Textbook of Pain is revised under new editorial leadership, and with a host of new, multidisciplinary international contributors.
Journal ArticleDOI
Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo
TL;DR: Findings point towards a regulatory function for nerve growth factor in vivo in the stimulation of sensory neuropeptide synthesis during prolonged inflammatory processes.
Journal ArticleDOI
Sensory defunctionalization induced by 8% topical capsaicin treatment in a model of ultraviolet-B-induced cutaneous hyperalgesia.
TL;DR: In this article, the authors explored the contribution of capsaicin-sensitive nociceptors in the development of mechanical and heat hyperalgesia in humans following ultraviolet-B (UVB) irradiation.
References
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Journal ArticleDOI
Delayed onset muscle soreness in neck/shoulder muscles
TL;DR: Soreness after exercise in the neck and shoulder seems not to be among the conditions that produce predominant musculoskeletal pain in females, and no gender differences were found in any of the parameters used to assess the development of DOMS.
Journal ArticleDOI
Muscular mechanical hyperalgesia revealed by behavioural pain test and c-Fos expression in the spinal dorsal horn after eccentric contraction in rats
TL;DR: An animal model of delayed onset muscle soreness is developed and it is demonstrated that the pain threshold of deep tissues (possibly of the muscle) decreased after ECC, and the existence of mechanical hyperalgesia in the muscle subjected to ECC is demonstrated.
Journal ArticleDOI
Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers: an updated review.
Camilla Staahl,Camilla Staahl,Anne Estrup Olesen,Anne Estrup Olesen,Trine Andresen,Trine Andresen,Lars Arendt-Nielsen,Asbjørn Mohr Drewes,Asbjørn Mohr Drewes +8 more
TL;DR: This review addresses how the efficacy of non-opioid analgesics have been assessed in human volunteers using experimental pain models to evaluate the mechanisms and pharmacokinetics of analgesics.
Journal ArticleDOI
Assessment of microvascular endothelial function in human skin.
TL;DR: It is shown that just acetylcholine and methacholine can currently be used with iontophoresis to allow sensitive and reproducible assessment of endothelial function.
Journal ArticleDOI
The sunburn pain model: the stability of primary and secondary hyperalgesia over 10 hours in a crossover setting.
TL;DR: The sunburn pain model provides a long time course of stable hyperalgesia with a high within-day stability and between-day repeatability for primary and secondary hyperalGESia.