Open AccessDOI
Inflammation and pain in skin and deep tissues
TLDR
Evaluate the change in sensitivity after inflammation inside and outside the irradiated skin and investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.Abstract:
Ultraviolet-B irradiation model has been used for many years as a translational model since it is well known to induce cutaneous inflammatory pain in both animals and humans. The aim of this study project was to evaluate time course and sensory changes induced by UVB and in particular: 1) evaluate the change in sensitivity after inflammation inside and outside the irradiated skin, 2) investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia, 3) investigate the effect on mechanical hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.read more
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Book Chapter
Wall and Melzack's textbook of pain
TL;DR: The Wall and Melzack's Textbook of Pain is revised under new editorial leadership, and with a host of new, multidisciplinary international contributors.
Journal ArticleDOI
Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo
TL;DR: Findings point towards a regulatory function for nerve growth factor in vivo in the stimulation of sensory neuropeptide synthesis during prolonged inflammatory processes.
Journal ArticleDOI
Sensory defunctionalization induced by 8% topical capsaicin treatment in a model of ultraviolet-B-induced cutaneous hyperalgesia.
TL;DR: In this article, the authors explored the contribution of capsaicin-sensitive nociceptors in the development of mechanical and heat hyperalgesia in humans following ultraviolet-B (UVB) irradiation.
References
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Journal ArticleDOI
Cutaneous vascular sensitivity to lower aliphatic alcohols and aldehydes in Orientals.
Jonathan K. Wilkin,Glenn Fortner +1 more
TL;DR: An ethnic predisposition to ethanol-provoked flushing among diverse Mongoloid populations may be the consequence of a delayed oxidation and accumulation of acetaldehyde, as well as a potent inhibitor of alcohol dehydrogenase.
Journal ArticleDOI
Mechanically induced axon reflex and hyperalgesia in human UV-B burn are reduced by systemic lidocaine.
TL;DR: The neurogenic axon reflex erythema (flare) following phasic mechanical stimulation in normal and in UV‐B irradiated skin was analyzed and low dose of systemic lidocaine suppressed mechanical hyperalgesia in sunburned skin and in the mechanically induced flare.
Journal ArticleDOI
Differential time courses of skin blood flow and hyperalgesia in the human sunburn reaction following ultraviolet irradiation of the skin
TL;DR: The response of skin to ultraviolet (UV) irradiation is an inflammation with pronounced vasodilation and hyperalgesia and the effect of repeated topical pre‐treatment 4 days prior to UV irradiation with 1.5 g of 0.04% capsaicin containing ointment was investigated.
Journal ArticleDOI
Nociceptor sensitization to mechanical and thermal stimuli in pig skin in vivo.
TL;DR: A pig model is set‐up in order to have more options for pharmacological intervention on primary hyperalgesia and to induce experimentally by ultraviolet‐B (UV‐B) irradiation in humans.