Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
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TLDR
A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).Abstract:
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.read more
Citations
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Journal ArticleDOI
Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors.
Takafumi Kusaba,Toshiyuki Nakayama,Kazuyuki Yamazumi,Yuichi Yakata,Ayumi Yoshizaki,Takeshi Nagayasu,Ichiro Sekine +6 more
TL;DR: It is suggested that p-STAT3 expression is an important factor related to carcinogenesis and/or tumour invasion of colorectal adenocarcinoma.
Journal ArticleDOI
Stat3 activation in human endometrial and cervical cancers
Chun Liang Chen,F. C. Hsieh,Jacqueline Lieblein,Jessica Brown,C. Chan,J. A. Wallace,G. Cheng,Brett Hall,Jiayuh Lin +8 more
TL;DR: In this paper, the authors examined tyrosine phosphorylation of Stat3 in multiple endometrial and cervical cancer tissues using tissue microarray slides as well as cancer cell lines to explore the possible activation of stat3.
Journal ArticleDOI
Mediation of growth hormone-dependent transcriptional activation by mammary gland factor/stat 5
Timothy J. J. Wood,Daniel Sliva,Peter E. Lobie,Tony J. Pircher,Fabrice Gouilleux,Hiroshi Wakao,Jan Gustafsson,Bernd Groner,Gunnar Norstedt,Lars-Arne Haldosén +9 more
TL;DR: Investigation of nuclear extracts from COS-7 cells transiently expressing transfected Stat 5 and growth hormone receptor cDNA revealed the growth hormone-dependent presence of specific DNA-binding proteins in these extracts, suggesting a role for phosphorylation of this residue in growth hormones-dependent activation of DNA- binding and transcription.
Book ChapterDOI
The Common γ-Chain for Multiple Cytokine Receptors
Kazuo Sugamura,Hironobu Asao,Motonari Kondo,Nobuyuki Tanaka,Naoto Ishii,Masataka Nakamura,Toshikazu Takeshita +6 more
TL;DR: Molecular identification of IL-2Rγ has led to knowledge for understanding the structures and signal-transducing functions of various cytokine receptors, and particularly has made a great contribution toward elucidation of the molecular mechanisms of human XSCID occurrence.
Journal ArticleDOI
Signaling pathways involved in MDSC regulation.
TL;DR: The role played by key signaling pathways such as PI3K, Ras, Jak/Stat and TGFb during myeloid development and how their deregulation under pathological conditions can lead to the generation of suppressive myeloids cells or MDSCs is discussed.
References
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Journal ArticleDOI
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Journal ArticleDOI
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
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Journal ArticleDOI
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