Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
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TLDR
A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).Abstract:
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.read more
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References
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Journal ArticleDOI
High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons
TL;DR: Results indicate that the signaling pathways for the two types of IFN and double-stranded RNA share common components or that their function depends on common enzymes or transcription factors.
Journal ArticleDOI
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TL;DR: Gel shift analysis revealed that these GAF proteins, detected after either EGF or IFN-gamma administration, specifically bound to the sis-inducible element of the c-fos promoter, participate in nuclear signaling in both EGF and EGF pathways.
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Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4
Helen Kotanides,Nancy C. Reich +1 more
TL;DR: IL-4 appears to transduce a signal to the nucleus through tyrosine phosphorylation of a latent DNA binding factor as well as a putative transcription factor found in the promoters of IL-4-responsive genes.
Journal ArticleDOI
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TL;DR: The data suggest that a 39 bp sequence is sufficient to confer transcriptional inducibility and can account in large part for the response of 6‐16.
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