Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
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TLDR
A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).Abstract:
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.read more
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Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase.
TL;DR: In transfected I1A cells, IRAK-K239A was still phosphorylated upon IL-1 stimulation and, surprisingly, still complemented all the defects in the mutant cells, indicating that IRAK must beosphorylated by a different kinase, and phospho-IRAK must play a role in IL- 1-mediated signaling that does not require its kinase activity.
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Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells
Seog Young Kim,Jin Wook Kang,Xinxin Song,Bo Kyoung Kim,Young Dong Yoo,Yong Tae Kwon,Yong Tae Kwon,Yong J. Lee +7 more
TL;DR: The results imply that removing CSCs may prompt non-CSCs in the tumor to convert into stem cells to maintain the equilibrium, and suggest that the IL-6-JAK1-STAT3 signal transduction pathway plays an important role in the conversion of non-cSCs into C SCs through regulation of OCT-4 gene expression.
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EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization
TL;DR: Emerging evidences suggest the existence of a direct mode of the EGFR pathway that is distinct from the traditional transduction pathway, which will facilitate the identification of patients that are likely to respond to these agents as well as future development of more effective anti-EGFR therapeutic interventions.
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Negative regulators of cytokine signal transduction
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The human papillomavirus E7 oncoprotein abrogates signaling mediated by interferon-alpha
TL;DR: The results suggest that HPV, via E7, targets p48, resulting in the loss of IFNalpha-mediated signal transduction and may provide a means by which HPV can avoid the innate immune system.
References
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Journal ArticleDOI
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Journal ArticleDOI
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
TL;DR: Observations suggest that SH2 and SH3 domains participate in the control of intracellular responses to growth factor stimulation.
Journal ArticleDOI
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