Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
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TLDR
A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).Abstract:
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.read more
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Journal ArticleDOI
Involvement of stat3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cells
Koji Shimozaki,Koji Shimozaki,Koichi Nakajima,Toshio Hirano,Shigekazu Nagata,Shigekazu Nagata +5 more
TL;DR: Results indicate that STAT3 activation is responsible for part of the G-CSF-induced differentiation of neutrophils but that another pathway, involving the expression of the MPO gene, that does not utilize the activated STAT3, is also required to fully differentiate the cells.
Journal ArticleDOI
STAT3 and epithelial-mesenchymal transitions in carcinomas.
TL;DR: The molecular, cellular, and microenvironmental factors that contribute to the pathophysiological activities of STAT3 during its regulation of EMT programs in human carcinomas are reviewed.
Journal ArticleDOI
Interaction Between the Components of the Interferon Gamma Receptor Complex
Serguei V. Kotenko,Lara S. Izotova,Brian P. Pollack,Thomas M. Mariano,Robert J. Donnelly,Geetha Muthukumaran,Jeffry R. Cook,Gianni Garotta,Olli Silvennoinen,James N. Ihle,Sidney Pestka +10 more
TL;DR: It is shown that the intracellular domain of IFN-γR2 is necessary for signaling as measured by MHC class I antigen induction.
Journal ArticleDOI
Constitutive and IFN‐γ‐induced nuclear import of STAT1 proceed through independent pathways
TL;DR: A non‐transferable nuclear targeting sequence in the STAT1 DNA‐binding domain is identified and characterized, critical for the interferon‐γ (IFN‐γ)‐induced nuclear import of phosphorylated STAT1 dimers and requires adjacent positively charged and hydrophobic residues for functioning.
Journal ArticleDOI
Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling
Anne Schroeder,Andreas Herrmann,Gregory Cherryholmes,Claudia M. Kowolik,Ralf Buettner,Sumanta K. Pal,Hua Yu,Gerhard Müller-Newen,Richard Jove +8 more
TL;DR: It is demonstrated that loss of AR expression results in STAT3 activation in prostate cancer cells, which indicates an opposing role of AR and STAT3 in prostate CSC development.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
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