Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
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TLDR
A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).Abstract:
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.read more
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Interferon-α Resistance in a Cutaneous T-Cell Lymphoma Cell Line Is Associated With Lack of STAT1 Expression
Wenn H. Sun,Carlos Pabon,Carlos Pabon,Yazan Alsayed,Yazan Alsayed,Paul P. Huang,Paul P. Huang,Sara Jandeska,Sara Jandeska,Shahab Uddin,Shahab Uddin,Leonidas C. Platanias,Leonidas C. Platanias,Steven T. Rosen,Steven T. Rosen +14 more
TL;DR: The development of an IFN alpha-resistant CTCL cell line (HUT78R), characterized by its ability to proliferate in high concentration of recombinant IFNalpha, which can be used as a model system to study IFN resistance.
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Expression of tissue factor correlates with grade of malignancy in human glioma.
TL;DR: TF belongs to the interferon receptor family and is one of the immediate early genes, suggesting that TF may participate in the regulation of cell growth, however, the correlation between the expression of TF and cell growth is still unclear.
Journal ArticleDOI
Nuclear Translocation of Phosphorylated STAT3 Is Essential for Vascular Endothelial Growth Factor-induced Human Dermal Microvascular Endothelial Cell Migration and Tube Formation
Yoko Yahata,Yuji Shirakata,Sho Tokumaru,Kenshi Yamasaki,Koji Sayama,Yasushi Hanakawa,Michael Detmar,Koji Hashimoto +7 more
TL;DR: Analysis of the role of STAT3 in the migration and tube formation of the human dermal microvascular endothelial cells (HDMEC) and a dominant-negative STAT3 using adenovirus vector system demonstrate that STAT3 and its phosphorylation are involved in the downstream pathway of V EGF/VEGFR interaction and regulate VEGF-induced HDMEC migration andtube formation.
Journal ArticleDOI
Synergistic action of pro-inflammatory agents: cellular and molecular aspects
TL;DR: The molecular mechanisms underlying the synergistic gene induction discussed in this review involve cooperative activation of transcription factors that function synergistically with nuclear factor κB activated by LPS and TNF‐α.
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IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes
Jens Wehinger,Fabrice Gouilleux,Bernd Groner,Juergen Finke,Roland Mertelsmann,Renate Weber-Nordt +5 more
TL;DR: Functional relevant STAT dimerization is influenced by the activated cytokine receptor as well as the specific STAT consensus sequence present in a specific gene promoter.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
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