Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
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TLDR
A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).Abstract:
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.read more
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Perturbation-response genes reveal signaling footprints in cancer gene expression.
Michael Schubert,Bertram Klinger,Martina Klünemann,Martina Klünemann,Anja Sieber,Anja Sieber,Florian Uhlitz,Florian Uhlitz,Sascha Sauer,Mathew J. Garnett,Nils Blüthgen,Nils Blüthgen,Julio Saez-Rodriguez,Julio Saez-Rodriguez +13 more
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Tumor Cell Responses to IFNγ Affect Tumorigenicity and Response to IL-12 Therapy and Antiangiogenesis
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Novel pathways for implantation and establishment and maintenance of pregnancy in mammals
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Chemokines in Oral Inflammatory Diseases: Apical Periodontitis and Periodontal Disease
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Sympathetic neurons can produce and respond to interleukin 6.
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TL;DR: In this article, it was shown that the addition of soluble IL-6 receptor (sIL-6R) and IL 6 enhances neuronal survival in the absence of nerve growth factor.
References
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