Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
TLDR
A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).Abstract:
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.read more
Citations
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Journal ArticleDOI
The Yin and Yang of type I interferon activity in bacterial infection
TL;DR: An increasing body of work shows that type I IFNs have an important role in the host response to bacterial infection, and can influence various immune effector mechanisms.
Journal ArticleDOI
The growing family of interferon regulatory factors
TL;DR: Understanding the molecular mechanisms by which the IRFs affect these important cellular events and IFN expression will contribute to a greater understanding of events leading to various viral, immune and malignant disease states and will suggest novel strategies for antiviral and immune modulatory therapy.
Journal ArticleDOI
Interleukin 10 secretion in relation to human IL-10 locus haplotypes
Joyce Eskdale,Grant Gallagher,Cor L. Verweij,Vivian Keijsers,Rudi G. J. Westendorp,Tom W J Huizinga +5 more
TL;DR: The ability to secrete interleukin 10 can vary in man according to the genetic composition of the IL-10 locus, and it is shown that the haplotype IL10.R2/IL10.G14 was associated with highestIL-10 secretion overall, whereas the haplotypes containing the allele IL 10.R3/IL11.R were associated with lowest IL- 10 secretion.
Journal ArticleDOI
Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
TL;DR: The cloning and characterization of Pip is described, a lymphoid-specific protein that is most likely NF-EM5.1 that binds the composite element only in the presence of PU.1 and exhibits a high degree of homology to the DNA-binding domains of members of the interferon regulatory factor (IRF) family.
Journal ArticleDOI
A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.
Dmitry Guschin,Neil C. Rogers,James Briscoe,Bruce A. Witthuhn,Diane Watling,Friedemann Horn,Sandra Pellegrini,Kiyoshi Yasukawa,Peter C. Heinrich,George R. Stark +9 more
TL;DR: A major role for JAK1 and the nonequivalence of JAK 1 and JAK2 in the IL‐6 response pathway are, nevertheless, clearly established for these cells.
References
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