Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
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TLDR
A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).Abstract:
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.read more
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Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response.
Frederick W. Quelle,Demin Wang,Tetsuya Nosaka,William E. Thierfelder,Dimitrios J. Stravopodis,Y. Weinstein,James N. Ihle +6 more
TL;DR: The studies presented here demonstrate that this region is also necessary and sufficient for the activation of Stat5A and Stat5B, and can disrupt Stat5 DNA binding activity, consistent with a role of Y-343 as a site of recruitment to the receptor.
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Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3.
Yuang-Taung Juang,William J. Lowther,M. Kellum,Wei-Chun Au,Rongtuan Lin,John Hiscott,Paula M. Pitha +6 more
TL;DR: IRF-3 and CBP/p300 are identified as integral components of the virus-induced complex that stimulates type 1 IFN gene transcription and implicates a novel mechanism by which adenovirus may overcome the antiviral effects of the IFN pathway.
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Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.
Georges Lutfalla,S J Holland,E Cinato,Danièle Monneron,Jérôme Reboul,Neil C. Rogers,J M Smith,G R Stark,Katheleen Gardiner,Knud Erik Mogensen +9 more
TL;DR: Together IFNAR2, CRFB4,IFNAR1 and AF1 form a cluster of class II cytokine receptor genes on human chromosome 21, establishing that together IFNARE2,CRFB4 and IFnAR2 form a clusters of class I cytokine receptors on human chromosomes 21.
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Cytokines in the Treatment of Cancer.
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Ciliary Neurotrophic Factor and Stress Stimuli Activate the Jak-STAT Pathway in Retinal Neurons and Glia
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References
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Journal ArticleDOI
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