Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
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TLDR
A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).Abstract:
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.read more
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Stimulation of interferon and cytokine gene expression by imiquimod and stimulation by Sendai virus utilize similar signal transduction pathways.
Klára Megyeri,Wei-Chun Au,István Rosztóczy,N. B. K. Raj,Richard L. Miller,Mark A. Tomai,Paula M. Pitha +6 more
TL;DR: The results indicate that imiquimod, similar to viral infection, stimulates expression of a large number of cytokine genes, including IFN-alpha/beta, and that the signal transduction pathway induced by both of these stimuli requires tyrosine kinase and protein kinase activity.
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Interleukin-4 Suppression of Tumor Necrosis Factor α-stimulated E-selectin Gene Transcription Is Mediated by STAT6 Antagonism of NF-κB *
TL;DR: It is demonstrated that IL-4 activates STAT6 in human vascular endothelial cells and that two STAT6 binding sites are present in the promoter of the E-selectin gene.
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Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300.
TL;DR: It is demonstrated that HIV transcription can be regulated in the nucleus by competitive binding of specific cytokine‐induced transcription factors to a discrete domain of a transcriptional coactivator.
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Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection.
Yejin Kim,Hyemin Kim,Seyeon Bae,Jiwon Choi,Sun Young Lim,Naeun Lee,Joo Myung Kong,Young-il Hwang,Jae Seung Kang,Wang Jae Lee +9 more
TL;DR: Vitamin C shows in vivo anti-viral immune responses at the early time of infection, especially against influenza virus, through increased production of IFN-α/β.
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Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7.
Tiziana Musso,James A. Johnston,Diana Linnekin,Luigi Varesio,Tammy K. Rowe,John J. O'Shea,Daniel W. McVicar +6 more
TL;DR: The findings suggest that JAK3 is functionally important in activated monocytes and cells of the myeloid lineage and is involved in signaling responses of cytokines that use the common gamma-chain of the IL-2 receptor.
References
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