Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
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TLDR
A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).Abstract:
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.read more
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IFNγ sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway
TL;DR: It is reported that IFNγ sensitizes resistant tumor cells with absent or low caspase-8 expression for apoptosis induced by death-inducing ligands or cytotoxic drugs by upregulating casp enzyme-8 through a Stat1/IRF1 dependent pathway.
Journal ArticleDOI
Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma.
Aruljothi Subramaniam,Muthu K. Shanmugam,Ekambaram Perumal,Feng Li,Alamelu Nachiyappan,Xiaoyun Dai,Shivananju Nanjunda Swamy,Kwang Seok Ahn,Alan Prem Kumar,B. K. H. Tan,Kam M. Hui,Gautam Sethi +11 more
TL;DR: The possible role of STAT3 signaling cascade and its interacting partners in the initiation of HCC is discussed and the role of various STAT3 regulated genes in HCC progression, inflammation, survival, invasion and angiogenesis is analyzed.
Journal ArticleDOI
STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition
Toshiyuki Fukada,Takuya Ohtani,Yuichi Yoshida,Takahiro Shirogane,Keigo Nishida,Koichi Nakajima,Masahiko Hibi,Toshio Hirano +7 more
TL;DR: An ‘orchestrating model’ for cytokine and growth factor action is proposed in which contradictory signals are orchestrated to produce a specific effect in a target cell.
Journal ArticleDOI
JAKs, STATs and Src kinases in hematopoiesis.
TL;DR: Cell and tissue-specificity of cytokine action appears to be determined by the nature of signal transduction pathways activated by cytokine/receptor interactions, and the integration of these diverse signaling cues from active JAK kinases, members of the Src-family kinases and STAT proteins, leads to cell proliferation, cell survival and differentiation, the end-point of the cytokin/growth factor stimulus.
Journal ArticleDOI
Interferon-resistant Human Melanoma Cells Are Deficient in ISGF3 Components, STAT1, STAT2, and p48-ISGF3γ
Lee H. Wong,Kenia Krauer,Irene Hatzinisiriou,Marie Estcourt,Peter Hersey,Nguyen Tam,Stephanie R. Edmondson,Rodney J. Devenish,Stephen John Ralph +8 more
TL;DR: It is concluded that a defect in the level of STAT1 and possibly all three ISGF3 components in IFN-resistant human melanoma cells may be a general phenomenon responsible for reduced cellular responsiveness of melanomas to IFNs.
References
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Journal ArticleDOI
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Journal ArticleDOI
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
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Journal ArticleDOI
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