Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
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TLDR
A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).Abstract:
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.read more
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Two tumour necrosis factor receptors: structure and function.
TL;DR: Tumour necrosis factor induces receptor oligomerization, an event that is believed to connect the receptors to downstream signalling pathways, and suggests that several TNF-R-associated proteins may initiate cytoplasmic signal transduction.
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Mig and IP-10: CXC chemokines that target lymphocytes
TL;DR: RHuMig and rIP‐10 share additional activities, including inhibition of neovascularization, inhibition of hematopoietic progenitor cells, and anti‐tumor effects, and that, despite their similar activities assayed in vitro, Mig and IP‐10/Crg‐2 may serve non‐redundant functions in vivo.
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The roles of IFNγ in protection against tumor development and cancer immunoediting
TL;DR: The capacity of IFN gamma and lymphocytes to not only provide protection against tumor development but also to sculpt the immunogenic phenotype of tumors that develop in an immunocompetent host is presented and introduced as a "cancer immunoediting" process.
Journal ArticleDOI
SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine
Warren S. Alexander,Robyn Starr,Robyn Starr,Jennifer Eve Fenner,Clare L. Scott,Clare L. Scott,Emanuela Handman,Naomi S. Sprigg,Naomi S. Sprigg,Jason Corbin,Jason Corbin,Ann L Cornish,Ann L Cornish,Rima Darwiche,Catherine M Owczarek,Thomas W.H. Kay,Nicos A. Nicola,Nicos A. Nicola,Paul J. Hertzog,Donald Metcalf,Donald Metcalf,Douglas J. Hilton,Douglas J. Hilton +22 more
TL;DR: It is indicated that SOCS1 is a key modulator of IFNgamma action, allowing the protective effects of this cytokine to occur without the risk of associated pathological responses.
Journal ArticleDOI
The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
Jian-Xin Lin,Thi-Sau Migone,Monica Tseng,Michael Friedmann,James A. Weatherbee,Li Zhou,Akira Yamauchi,Eda T. Bloom,Judy A. Mietz,Susan D. John,Warren J. Leonard +10 more
TL;DR: These studies demonstrate that a single cytokine can activate different combinations of Stat proteins under different physiological conditions, and also indicate two mechanisms by which distinct cytokines can activate the same Stat protein.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
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Journal ArticleDOI
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