Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
TLDR
A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).Abstract:
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.read more
Citations
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Journal ArticleDOI
Stat3 Activation Is Required for Cellular Transformation by v-src
TL;DR: It is concluded that Stat3 has a necessary role in v- src transformation and wild-type Stat3 enhances the transforming potential of v-src while three dominant negative Stat3 mutants inhibit v-srctransformation.
Journal ArticleDOI
Interferon signaling and treatment outcome in chronic hepatitis C
Magdalena Sarasin-Filipowicz,Edward J. Oakeley,Francois H.T. Duong,Verena Christen,Luigi Terracciano,Witold Filipowicz,Markus H. Heim +6 more
TL;DR: The concept that activation of the endogenous IFN system in CHC not only is ineffective in clearing the infection but also may impede the response to therapy, most likely by inducing a refractory state of the IFN signaling pathway, is supported.
Journal ArticleDOI
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.
Xiaojing Ma,J. M. Chow,Giorgia Gri,G. Carra,F. Gerosa,S. F. Wolf,R. Dzialo,Giorgio Trinchieri +7 more
TL;DR: It is shown here that IFN-gamma enhances IL-12 production mostly by priming phagocytic cells for lipopolysaccharide (LPS)-induced transcription of the IL- 12 p40 gene, which encodes the heavy chain of theIL-12 heterodimer, which represents an important amplifying mechanism in the inflammatory response to infections.
Journal ArticleDOI
Cytokines and the hepatic acute-phase response.
G. Ramadori,Bruno Christ +1 more
TL;DR: Attention is payed to the differences recently detected between the locally and systemically induced acute-phase response--in particular, the newest findings concerning the meaning of single cytokines.
Journal ArticleDOI
Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene.
Thomas Holtschke,Jürgen Löhler,Yuka Kanno,Thomas Fehr,N.A. Giese,Frank Rosenbauer,Jing Lou,Klaus-Peter Knobeloch,Lucia Gabriele,Jeffrey F. Waring,Martin F. Bachmann,Rolf M. Zinkernagel,Herbert C. Morse,Keiko Ozato,Ivan Horak +14 more
TL;DR: A novel role for ICSBP is suggested in regulating the proliferation and differentiation of hematopoietic progenitor cells in mice with a null mutation of ICS BP.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
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