Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
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TLDR
A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).Abstract:
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.read more
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Journal ArticleDOI
Transcription factors, normal myeloid development, and leukemia.
TL;DR: In the hematopoietic system, stem cells undergo a process of commitment to multipotential progenitors, which in turn give rise to mature blood cells.
Journal ArticleDOI
Inhibition of Stat1-mediated gene activation by PIAS1.
TL;DR: The results identify PIAS1 as a specific inhibitor of Stat1-mediated gene activation and suggest that there may exist a specific PIAS inhibitor in every STAT signaling pathway.
Journal ArticleDOI
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.
Akihiko Yoshimura,Tadashi Ohkubo,Toru Kiguchi,Nancy A. Jenkins,Debra J. Gilbert,Neal G. Copeland,Takahiko Hara,Atsushi Miyajima +7 more
TL;DR: A novel gene, CIS (cytokine inducible SH2‐containing protein), which is induced in hematopoietic cells by a subset of cytokines but not by stem cell factor, granulocyte colony‐stimulating factor and IL6 is isolated.
Journal ArticleDOI
Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus
Michael Karin,Tony Hunter +1 more
TL;DR: This work has shown that transcription factors are kept in a latent state in the cytoplasm and are translocated into the nucleus upon activation, where they phosphorylate target transcription factors.
Journal ArticleDOI
Twenty proteins containing a C-terminal SOCS box form five structural classes
Douglas J. Hilton,Rachael T. Richardson,Warren S. Alexander,Elizabeth M. Viney,Tracy A. Willson,Naomi S. Sprigg,Robyn Starr,Sandra E. Nicholson,Donald Metcalf,Nicos A. Nicola +9 more
TL;DR: Four new SOCS proteins (SOCS-4 to SOCS-7) containing an SH2 domain and a SOCS box are described, and three new families of proteins that contain either WD-40 repeats (WSB-1 and -2), SPRY domains (SSB-1 to -3) or ankyrin repeats (ASB-3) N-terminal of the SOCSbox are described.
References
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Journal ArticleDOI
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Journal ArticleDOI
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
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Journal ArticleDOI
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
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Journal ArticleDOI
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