Keeping Out the Bad Guys: Gateway to Cellular Target Therapy
Reads0
Chats0
TLDR
It is shown that lack of CCR1 prevents the accumulation of M MP-expressing cells at the invasion front and suppresses tumor invasion, providing the possibility of a novel therapeutic strategy for advanced cancer--prevention of the recruitment of MMP- expressing cells by chemokine receptor antagonist.Abstract:
Tumor-stromal interaction is implicated in many stages of tumor development, although it remains unclear how genetic lesions in tumor cells affect stromal cells. We have recently shown that inactivation of transforming growth factor-beta family signaling within colon cancer epithelium increases chemokine CC chemokine ligand 9 (CCL9) and promotes recruitment of the matrix metalloproteinase (MMP)-expressing stromal cells that carry CC chemokine receptor 1 (CCR1), the cognate receptor for CCL9. We have further shown that lack of CCR1 prevents the accumulation of MMP-expressing cells at the invasion front and suppresses tumor invasion. These results provide the possibility of a novel therapeutic strategy for advanced cancer--prevention of the recruitment of MMP-expressing cells by chemokine receptor antagonist.read more
Citations
More filters
Journal Article
TNF-α in obesity-associated colon cancer
TL;DR: The central role of TNF-α, the prototypical pro-inflammatory cytokine, in the pathophysiology of obesity-associated colon carcinogenesis is discussed.
Journal ArticleDOI
1‑calcium phosphate‑uracil, a synthesized pyrimidine derivative agent, has anti‑proliferative, pro‑apoptotic and anti‑invasion effects on multiple tumor cell lines
TL;DR: The present study was the first, to the best of the authors' knowledge, to demonstrate the function of 1- CP-U in tumor proliferation, apoptosis and invasion with specific effects against cancer cells in vitro, suggesting 1-CP-U as a potential novel anticancer agent.
Journal ArticleDOI
CCR1 (chemokine (C-C motif) receptor 1)
Qiang Gao,Jia Fan +1 more
TL;DR: Review on CXCR1 (chemokine (C-X-C motif) receptor 1), with data on DNA, on the protein encoded, and where the gene is implicated.
ReportDOI
Uncovering the Hidden Molecular Signatures of Breast Cancer
TL;DR: An open and accessible framework that will be used to quickly and thoroughly understand the processes that are at play in new tumour cases is produced, allowing to understand how different tumor processes work together, and to refine the authors' models to better reflect the human disease.
Book ChapterDOI
Role of Bone Marrow-Derived CCR1+ cells in colon cancer invasion and metastasis
TL;DR: Results indicate that loss of TGF-β family signaling in CRC epithelium causes accumulation of iMCs that promote tumor invasion, and that CCR1 antagonists can provide anti-metastatic therapies for patients with disseminated CRC cells in the liver.
References
More filters
Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
New functions for the matrix metalloproteinases in cancer progression
Mikala Egeblad,Zena Werb +1 more
TL;DR: It is shown that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer.
Journal ArticleDOI
Fibroblasts in cancer
TL;DR: Fibroblasts are a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
Journal ArticleDOI
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
Journal ArticleDOI
Tumour-cell invasion and migration: diversity and escape mechanisms
Peter Friedl,Katarina Wolf +1 more
TL;DR: Cancer cells possess a broad spectrum of migration and invasion mechanisms and learning more about the cellular and molecular basis of these different migration/invasion programmes will help to understand how cancer cells disseminate and lead to new treatment strategies.
Related Papers (5)
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Rosandra N. Kaplan,Rebecca D. Riba,Stergios Zacharoulis,Anna H. Bramley,Loic Vincent,Carla Costa,Daniel D. MacDonald,David K. Jin,Koji Shido,Scott A. Kerns,Zhenping Zhu,Daniel J. Hicklin,Yan Wu,Jeffrey L. Port,Nasser K. Altorki,Elisa Port,Davide Ruggero,Sergey V. Shmelkov,Kristian K. Jensen,Shahin Rafii,David Lyden +20 more