Keeping Out the Bad Guys: Gateway to Cellular Target Therapy
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TLDR
It is shown that lack of CCR1 prevents the accumulation of M MP-expressing cells at the invasion front and suppresses tumor invasion, providing the possibility of a novel therapeutic strategy for advanced cancer--prevention of the recruitment of MMP- expressing cells by chemokine receptor antagonist.Abstract:
Tumor-stromal interaction is implicated in many stages of tumor development, although it remains unclear how genetic lesions in tumor cells affect stromal cells. We have recently shown that inactivation of transforming growth factor-beta family signaling within colon cancer epithelium increases chemokine CC chemokine ligand 9 (CCL9) and promotes recruitment of the matrix metalloproteinase (MMP)-expressing stromal cells that carry CC chemokine receptor 1 (CCR1), the cognate receptor for CCL9. We have further shown that lack of CCR1 prevents the accumulation of MMP-expressing cells at the invasion front and suppresses tumor invasion. These results provide the possibility of a novel therapeutic strategy for advanced cancer--prevention of the recruitment of MMP-expressing cells by chemokine receptor antagonist.read more
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Journal ArticleDOI
Mouse models of colon cancer.
TL;DR: What models have been developed most recently and what they have taught us about colon cancer formation, progression, and possible treatment strategies are discussed.
Journal ArticleDOI
Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling
Masahiro Sonoshita,Masahiro Aoki,Haruhiko Fuwa,Koji Aoki,Hisahiro Hosogi,Yoshiharu Sakai,Hiroki Hashida,Arimichi Takabayashi,Makoto Sasaki,Sylvie Robine,Kazuyuki Itoh,Kiyoko Yoshioka,Fumihiko Kakizaki,Takanori Kitamura,Masanobu Oshima,Masanobu Oshima,Makoto Mark Taketo +16 more
TL;DR: It is shown that Aes (or Grg5) gene functions as an endogenous metastasis suppressor and inhibition of Notch signaling can be a promising strategy for prevention and treatment of colon cancer metastasis.
Journal ArticleDOI
LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis
Zhiyu Wang,Tjing Yung Loo,Jiangang Shen,Neng Wang,Dongmei Wang,Depo Yang,Sui Lin Mo,Xin Yuan Guan,Jianping Chen +8 more
TL;DR: The results suggested that LDH-A inhibition might offer a promising therapeutic strategy for breast cancer.
Journal ArticleDOI
Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model
Takanori Kitamura,Teruaki Fujishita,Pius Loetscher,Laszlo Revesz,Hiroki Hashida,Shinae Kizaka-Kondoh,Masahiro Aoki,Makoto Mark Taketo +7 more
TL;DR: It is suggested that CCR1 antagonists can provide antimetastatic therapies for patients with disseminated colon cancer in the liver because of their role in tumor invasion and metastasis.
Journal ArticleDOI
Genetic Engineering of Mesenchymal Stem Cells and Its Application in Human Disease Therapy
TL;DR: The current understanding of the use of genetically engineered mesenchymal stem cells in human disease therapy with emphasis on genetic modifications aimed to improve survival, homing, angiogenesis, and heart function after myocardial infarction is presented.
References
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Journal ArticleDOI
Pivotal role of CXCR3 in melanoma cell metastasis to lymph nodes.
Kenji Kawada,Masahiro Sonoshita,Hiromi Sakashita,Arimichi Takabayashi,Yoshio Yamaoka,Toshiaki Manabe,Kayo Inaba,Nagahiro Minato,Masanobu Oshima,Makoto Mark Taketo +9 more
TL;DR: It is shown that mouse B16F10 melanoma cells constitutively express chemokine receptor CXCR3, and that its ligands CXCL9/Mig, CxCL10/IP-10, and CX CL11/I-TAC induce cellular responses in vitro, such as actin polymerization, migration, invasion, and cell survival.
Journal ArticleDOI
Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice
TL;DR: Results indicate that an increased level of PGE2 enhances macrophage infiltration, and that they are activated through epithelial cells by the gastric flora, resulting in gastric metaplasia and tumorous growth.
Journal ArticleDOI
Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes
Kenji Kawada,Hisahiro Hosogi,Masahiro Sonoshita,Hiromi Sakashita,Toshiaki Manabe,Yasuyuki Shimahara,Yoshiharu Sakai,Arimichi Takabayashi,Masanobu Oshima,Makoto Mark Taketo +9 more
TL;DR: It is shown that some human colon cancer cell lines express CXCR3 constitutively, and activation of CX CR3 with its ligands stimulates colon cancer metastasis preferentially to the draining lymph nodes with poorer prognosis.
Journal ArticleDOI
Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1.
Meina Liang,Cornell Mallari,Mary Rosser,Ng Howard P,Karen May,Monahan Sean D,John G. Bauman,Imadul Islam,Ghannam Ameen F,Brad O. Buckman,Ken Shaw,Guo-Ping Wei,Wei Xu,Zuchun Zhao,Elena Ho,Jun Shen,Huynh Oanh,Babu Subramanyam,Ron Vergona,Dennis D. Taub,Laura Dunning,Susan Harvey,R. Michael Snider,Joseph Hesselgesser,Michael M. Morrissey,H. Daniel Perez,Richard Horuk +26 more
TL;DR: This study is the first to demonstrate that a non-peptide chemokine receptor antagonist is efficacious in an animal model of an autoimmune disease and identified a potent, selective, and orally available CCR1 antagonist that may be useful in the treatment of chronic inflammatory diseases.
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