Keeping Out the Bad Guys: Gateway to Cellular Target Therapy
TLDR
It is shown that lack of CCR1 prevents the accumulation of M MP-expressing cells at the invasion front and suppresses tumor invasion, providing the possibility of a novel therapeutic strategy for advanced cancer--prevention of the recruitment of MMP- expressing cells by chemokine receptor antagonist.Abstract:
Tumor-stromal interaction is implicated in many stages of tumor development, although it remains unclear how genetic lesions in tumor cells affect stromal cells. We have recently shown that inactivation of transforming growth factor-beta family signaling within colon cancer epithelium increases chemokine CC chemokine ligand 9 (CCL9) and promotes recruitment of the matrix metalloproteinase (MMP)-expressing stromal cells that carry CC chemokine receptor 1 (CCR1), the cognate receptor for CCL9. We have further shown that lack of CCR1 prevents the accumulation of MMP-expressing cells at the invasion front and suppresses tumor invasion. These results provide the possibility of a novel therapeutic strategy for advanced cancer--prevention of the recruitment of MMP-expressing cells by chemokine receptor antagonist.read more
Citations
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Mouse models of colon cancer.
TL;DR: What models have been developed most recently and what they have taught us about colon cancer formation, progression, and possible treatment strategies are discussed.
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Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling
Masahiro Sonoshita,Masahiro Aoki,Haruhiko Fuwa,Koji Aoki,Hisahiro Hosogi,Yoshiharu Sakai,Hiroki Hashida,Arimichi Takabayashi,Makoto Sasaki,Sylvie Robine,Kazuyuki Itoh,Kiyoko Yoshioka,Fumihiko Kakizaki,Takanori Kitamura,Masanobu Oshima,Masanobu Oshima,Makoto Mark Taketo +16 more
TL;DR: It is shown that Aes (or Grg5) gene functions as an endogenous metastasis suppressor and inhibition of Notch signaling can be a promising strategy for prevention and treatment of colon cancer metastasis.
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LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis
Zhiyu Wang,Tjing Yung Loo,Jiangang Shen,Neng Wang,Dongmei Wang,Depo Yang,Sui Lin Mo,Xin Yuan Guan,Jianping Chen +8 more
TL;DR: The results suggested that LDH-A inhibition might offer a promising therapeutic strategy for breast cancer.
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Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model
Takanori Kitamura,Teruaki Fujishita,Pius Loetscher,Laszlo Revesz,Hiroki Hashida,Shinae Kizaka-Kondoh,Masahiro Aoki,Makoto Mark Taketo +7 more
TL;DR: It is suggested that CCR1 antagonists can provide antimetastatic therapies for patients with disseminated colon cancer in the liver because of their role in tumor invasion and metastasis.
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Genetic Engineering of Mesenchymal Stem Cells and Its Application in Human Disease Therapy
TL;DR: The current understanding of the use of genetically engineered mesenchymal stem cells in human disease therapy with emphasis on genetic modifications aimed to improve survival, homing, angiogenesis, and heart function after myocardial infarction is presented.
References
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The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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New functions for the matrix metalloproteinases in cancer progression
Mikala Egeblad,Zena Werb +1 more
TL;DR: It is shown that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer.
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Fibroblasts in cancer
TL;DR: Fibroblasts are a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
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Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
Journal ArticleDOI
Tumour-cell invasion and migration: diversity and escape mechanisms
Peter Friedl,Katarina Wolf +1 more
TL;DR: Cancer cells possess a broad spectrum of migration and invasion mechanisms and learning more about the cellular and molecular basis of these different migration/invasion programmes will help to understand how cancer cells disseminate and lead to new treatment strategies.
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