Long non-coding RNAs: modulators of nuclear structure and function
Jan H. Bergmann,David L. Spector +1 more
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TLDR
Recent studies that characterize the molecular function of a subset of lncRNAs in the regulation and fine-tuning of nuclear state are reviewed.About:
This article is published in Current Opinion in Cell Biology.The article was published on 2014-02-01 and is currently open access. It has received 211 citations till now. The article focuses on the topics: Scaffold/matrix attachment region & Regulation of gene expression.read more
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The Landscape of long noncoding RNA classification
TL;DR: The conceptual guidelines that have emerged for their classification and functional annotation based on expanding and more comprehensive use of large systems biology-based datasets are described.
Journal ArticleDOI
Non-coding RNAs as drug targets
Masayuki Matsui,David R. Corey +1 more
TL;DR: The growing field of ncRNA — including microRNA, intronic RNA, repetitive RNA and long non-coding RNA — is discussed and the potential and challenges in their therapeutic exploitation are assessed.
Journal ArticleDOI
Chromatin Replication and Epigenome Maintenance
Constance Alabert,Anja Groth +1 more
TL;DR: In this paper, the authors discuss the importance of chromatin structure and organization in eukaryotic genomes and their importance in maintaining the integrity of both genome and epigenome integrity with severe consequences for the organism.
Journal ArticleDOI
Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss
Gayatri Arun,Sarah D. Diermeier,Martin Akerman,Kung-Chi Chang,Kung-Chi Chang,J. Erby Wilkinson,Stephen Hearn,Youngsoo Kim,A. Robert MacLeod,Adrian R. Krainer,Adrian R. Krainer,Larry Norton,Edi Brogi,Mikala Egeblad,David L. Spector,David L. Spector +15 more
TL;DR: It is reported that genetic loss or systemic knockdown of Malat1 using antisense oligonucleotides (ASOs) in the MMTV-PyMT- and Her2/neu-amplified tumor organoids model results in slower tumor growth accompanied by significant differentiation into cystic tumors and a reduction in metastasis.
Journal ArticleDOI
Therapeutic Targeting of Long Non-Coding RNAs in Cancer.
TL;DR: Examples of lncRNAs that demonstrate the diversity of their function in various cancer types are discussed and recent advances in nucleic acid drug development with a focus on oligonucleotide-based therapies as a novel approach to inhibit tumor progression are discussed.
References
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Björn Schwanhäusser,Dorothea Busse,Na Li,Gunnar Dittmar,Johannes Schuchhardt,Jana Wolf,Wei Chen,Matthias Selbach +7 more
TL;DR: Using a quantitative model, the first genome-scale prediction of synthesis rates of mRNAs and proteins is obtained and it is found that the cellular abundance of proteins is predominantly controlled at the level of translation.
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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Rajnish A. Gupta,Nilay Shah,Kevin C. Wang,Jeewon Kim,Hugo M. Horlings,David J. Wong,Miao-Chih Tsai,Tiffany Hung,Pedram Argani,John L. Rinn,Yulei Wang,Pius Brzoska,Benjamin Kong,Rui-Chun Li,Robert B. West,Marc J. van de Vijver,Saraswati Sukumar,Howard Y. Chang +17 more
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Landscape of transcription in human cells
Sarah Djebali,Carrie A. Davis,Angelika Merkel,Alexander Dobin,Timo Lassmann,Ali Mortazavi,Ali Mortazavi,Andrea Tanzer,Julien Lagarde,Wei Lin,Felix Schlesinger,Chenghai Xue,Georgi K. Marinov,Jainab Khatun,Brian A. Williams,Chris Zaleski,Joel Rozowsky,Marion S. Röder,Felix Kokocinski,Rehab F. Abdelhamid,Tyler Alioto,Igor Antoshechkin,Michael T. Baer,Nadav Bar,Philippe Batut,Kimberly Bell,Ian Bell,Sudipto K. Chakrabortty,Xian Chen,Jacqueline Chrast,Joao Curado,Thomas Derrien,Jorg Drenkow,Erica Dumais,Jacqueline Dumais,Radha Duttagupta,Emilie Falconnet,Meagan Fastuca,Kata Fejes-Toth,Pedro G. Ferreira,Sylvain Foissac,Melissa J. Fullwood,Hui Gao,David Gonzalez,Assaf Gordon,Harsha P. Gunawardena,Cédric Howald,Sonali Jha,Rory Johnson,Philipp Kapranov,Brandon King,Colin Kingswood,Oscar Junhong Luo,Eddie Park,Kimberly Persaud,Jonathan B. Preall,Paolo Ribeca,Brian A. Risk,Daniel Robyr,Michael Sammeth,Lorian Schaffer,Lei-Hoon See,Atif Shahab,Jørgen Skancke,Ana Maria Suzuki,Hazuki Takahashi,Hagen Tilgner,Diane Trout,Nathalie Walters,Huaien Wang,John A. Wrobel,Yanbao Yu,Xiaoan Ruan,Yoshihide Hayashizaki,Jennifer Harrow,Mark Gerstein,Tim Hubbard,Alexandre Reymond,Stylianos E. Antonarakis,Gregory J. Hannon,Morgan C. Giddings,Morgan C. Giddings,Yijun Ruan,Barbara J. Wold,Piero Carninci,Roderic Guigó,Thomas R. Gingeras,Thomas R. Gingeras +87 more
TL;DR: Evidence that three-quarters of the human genome is capable of being transcribed is reported, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs that prompt a redefinition of the concept of a gene.
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