Open AccessJournal Article
Marine natural products as anticancer drugs
TLDR
This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.Abstract:
The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.read more
Citations
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Journal ArticleDOI
Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
Journal ArticleDOI
Sponge-Associated Microorganisms: Evolution, Ecology, and Biotechnological Potential
TL;DR: The ecology of sponge-microbe associations is examined, including the establishment and maintenance of these sometimes intimate partnerships, the varied nature of the interactions (ranging from mutualism to host-pathogen relationships), and the broad-scale patterns of symbiont distribution.
Journal ArticleDOI
Natural compounds for cancer treatment and prevention
Stefania Nobili,Donatella Lippi,Ewa Witort,Martino Donnini,L Bausi,Enrico Mini,Sergio Capaccioli +6 more
TL;DR: The main natural compounds used in cancer therapy and prevention, the historical aspects of their application and pharmacognosy, and some critical aspects of current cancer chemotherapy are discussed, focusing on genetics and genomics.
Journal ArticleDOI
Natural products as leads to anticancer drugs.
TL;DR: Semisynthesis processes of new compounds, obtained by molecular modification of the functional groups of lead compounds, are able to generate structural analogues with greater pharmacological activity and with fewer side effects.
Journal ArticleDOI
Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella.
Eric W. Schmidt,James T. Nelson,David A. Rasko,Sebastian Sudek,Jonathan A. Eisen,Margo G. Haygood,Jacques Ravel +6 more
TL;DR: The full sequencing and functional expression of a marine natural-product pathway from an obligate symbiont is presented, and a related cluster was identified in Trichodesmium erythraeum IMS101, an important bloom-forming cyanobacterium.
References
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Journal Article
LU103793 (NSC D-669356): a synthetic peptide that interacts with microtubules and inhibits mitosis.
TL;DR: The results suggest that LU103793 exerts its cytotoxic activity primarily through disruption of microtubule organization.
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Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase.
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Structure–activity relationships of Halichondrin B analogues: modifications at C.30–C.38
TL;DR: Structurally simplified analogues of halichondrin B were prepared by total synthesis and found to retain potent cell growth inhibitory activity in vitro.
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Psammaplin A, a natural phenolic compound, has inhibitory effect on human topoisomerase II and is cytotoxic to cancer cells.
TL;DR: It is concluded that PSA has Topo II inhibitory activity, and its cytotoxicity to cancer cells is not so strongly affected by Pgp-associated MDR phenotype in comparison with some Topo III inhibitory anticancer drugs used in the clinic.
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Compounds produced from potential tunicate-blue-green algal symbiosis: A review
H L Sings,K L Rinehart +1 more
TL;DR: There is evidence which supports the argument that the metabolic origin of certain ascidian metabolites resides in the alga, or is due to a collaborative effort of both organisms.