Open AccessJournal Article
Marine natural products as anticancer drugs
TLDR
This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.Abstract:
The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.read more
Citations
More filters
Journal ArticleDOI
Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
Journal ArticleDOI
Sponge-Associated Microorganisms: Evolution, Ecology, and Biotechnological Potential
TL;DR: The ecology of sponge-microbe associations is examined, including the establishment and maintenance of these sometimes intimate partnerships, the varied nature of the interactions (ranging from mutualism to host-pathogen relationships), and the broad-scale patterns of symbiont distribution.
Journal ArticleDOI
Natural compounds for cancer treatment and prevention
Stefania Nobili,Donatella Lippi,Ewa Witort,Martino Donnini,L Bausi,Enrico Mini,Sergio Capaccioli +6 more
TL;DR: The main natural compounds used in cancer therapy and prevention, the historical aspects of their application and pharmacognosy, and some critical aspects of current cancer chemotherapy are discussed, focusing on genetics and genomics.
Journal ArticleDOI
Natural products as leads to anticancer drugs.
TL;DR: Semisynthesis processes of new compounds, obtained by molecular modification of the functional groups of lead compounds, are able to generate structural analogues with greater pharmacological activity and with fewer side effects.
Journal ArticleDOI
Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella.
Eric W. Schmidt,James T. Nelson,David A. Rasko,Sebastian Sudek,Jonathan A. Eisen,Margo G. Haygood,Jacques Ravel +6 more
TL;DR: The full sequencing and functional expression of a marine natural-product pathway from an obligate symbiont is presented, and a related cluster was identified in Trichodesmium erythraeum IMS101, an important bloom-forming cyanobacterium.
References
More filters
Journal ArticleDOI
Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4.
Massimo Broggini,Sergio Marchini,Emanuela Galliera,Patrizia Borsotti,Giulia Taraboletti,Eugenio Erba,Marina Sironi,Jose Jimeno,Glynn Faircloth,Raffaella Giavazzi,Maurizio D'Incalci +10 more
TL;DR: It is demonstrated that aplidine inhibits the growth and induces apoptosis in MOLT-4 cells through the inhibition of V EGF secretion which blocks the VEGF/VEGFR-1 autocrine loop necessary for the growth of these cells.
Journal ArticleDOI
Phenolic constituents of Psammaplysilla
Emilio Quiñoá,Phillip Crews +1 more
TL;DR: The cytotoxic extract of Psammaplysilla sp. collected from Tonga contains monobromo tyrosine derivatives, 3-bromo-4-hydroxyphenylacetonitrile (1), which is known and psammaplin A (2) which is the first disulfide to be isolated from a sponge.
Journal ArticleDOI
Synthesis and antitumor activity of novel dolastatin 10 analogs
Koichi Miyazaki,Motohiro Kobayashi,Tsugitaka Natsume,Masaaki Gondo,Takashi Mikami,Kyoichi Sakakibara,Shigeru Tsukagoshi +6 more
TL;DR: Novel dolastatin 10 analogs each modified at one of the constituent amino acid derivatives, were synthesized and their antitumor activity was evaluated against P388 leukemia in mice, showing excellent activity in vivo.
Journal ArticleDOI
Natural products as probes of cell biology: 20 years of didemnin research.
TL;DR: The didemnin field illustrates how natural product chemistry may be used as a critical tool for the study of cell biology, with work directed towards understanding how this group of natural products interact with fundamental processes such as cell proliferation, protein biosynthesis, and apoptosis.
Journal ArticleDOI
Tubulin as a Target for Anticancer Drugs: Agents which Interact with the Mitotic Spindle
TL;DR: In this paper, a review describes both the natural and synthetic agents which are known to interact with tubulin, including colchicine, vinca alkaloid, rhizoxin/maytansine, and tubulin sulfhydryl binding sites.