Open AccessJournal Article
Marine natural products as anticancer drugs
TLDR
This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.Abstract:
The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.read more
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Drug Conjugates Such as Antibody Drug Conjugates (ADCs), Immunotoxins and Immunoliposomes Challenge Daily Clinical Practice
TL;DR: Targeted drug delivery by drug conjugates is a new emerging class of anti-cancer therapy that may play a major role in the future.
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Sample Processing Impacts the Viability and Cultivability of the Sponge Microbiome.
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Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes.
Marilia Barreca,Virginia Spanò,Alessandra Montalbano,Mercedes Cueto,Ana R Díaz Marrero,Irem Deniz,Ayşegül Erdoğan,Lada Lukić Bilela,Corentin Moulin,Elisabeth Taffin-de-Givenchy,Filippo Spriano,Giuseppe Perale,Mohamed Mehiri,Ana Rotter,Olivier P. Thomas,Paola Barraja,Susana P. Gaudêncio,Francesco Bertoni +17 more
TL;DR: This review focuses on the bioactive molecules derived from the marine environment with anticancer activity, discussing their families, origin, structural features and therapeutic use.
Journal ArticleDOI
Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.
Liliya V. Frolova,Igor V. Magedov,Anntherese E. Romero,Menuka Karki,Isaiah Otero,Kathryn Hayden,Nikolai M. Evdokimov,Laetitia Moreno Y Banuls,Shiva K. Rastogi,Ross W.R. Smith,Shi-Long Lu,Robert Kiss,Charles B. Shuster,Ernest Hamel,Tania Betancourt,Snezna Rogelj,Alexander Kornienko +16 more
TL;DR: Synthetic chemistry was developed to access the marine alkaloid rigidins and over 40 synthetic analogues based on the 7-deazahypoxanthine skeletons, finding that these compounds have significant potential as new anticancer agents.
Journal ArticleDOI
LC-MS-based metabolomics study of marine bacterial secondary metabolite and antibiotic production in Salinispora arenicola.
TL;DR: An LC-MS-based metabolomics approach was used to characterise the variation in secondary metabolite production due to changes in the salt content of the growth media as well as across different growth periods (incubation times), and indicated that a 14 day incubation period is optimal for the maximum production of rifamycin B.
References
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Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
David J. Newman,Gordon M. Cragg +1 more
TL;DR: There are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase II/III clinical trials in cancer, analgesia, allergy, and cognitive diseases.
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Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle.
TL;DR: This review describes the biochemistry of tubulin, microtubules, and the mitotic spindle and describes the natural and synthetic agents which are known to interact with tubulin.