Open AccessJournal Article
Marine natural products as anticancer drugs
TLDR
This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.Abstract:
The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.read more
Citations
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Synthesis of polymetallic macrocyclic terpene-derived hybrids
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Potential of four marine-derived fungi extracts as anti-proliferative and cell death-inducing agents in seven human cancer cell lines
Alice A. Ramos,Maria Prata-Sena,Bruno Castro-Carvalho,Tida Dethoup,Suradet Buttachon,Anake Kijjoa,Eduardo Rocha +6 more
TL;DR: It is demonstrated, for the first time, that extracts of Neosartorya paulistensis and NeosArtorya siamensis have selective anti-proliferative and cell death activities in HepG2, HCT16 and A375 cells.
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Design and synthesis of substituted dihydropyrimidinone derivatives as cytotoxic and tubulin polymerization inhibitors.
Sravani Sana,Ramya Tokala,Deepti Madanlal Bajaj,Narayana Nagesh,Kiran Kumar Bokara,Gaddam Kiranmai,Uppu Jaya Lakshmi,Swapna Vadlamani,Venu Talla,Nagula Shankaraiah +9 more
TL;DR: Cell cycle analysis revealed that compound 10f arrested the cells at G2/M phase in a dose-dependent manner and compounds containing α-haloacrylamide (10a-g) functionality found to exhibit significant inhibition of tubulin polymerization with microtubule destabilizing properties.
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Chemotherapeutic Effects of Bioassay-Guided Extracts of the American Cockroach, Periplaneta americana
Xiaoyu Wang,Zheng Chun He,Zheng Chun He,Liyan Song,Shawn D. Spencer,Leixiang Yang,Fang Peng,Guangming Liu,Ming-Hui Hu,Haibo Li,Haibo Li,Xiumei Wu,Su Zeng,Rolf Hilgenfeld,Joachim Stöckigt,Yu Zhao,Yu Zhao,Jin Fu Qian +17 more
TL;DR: The present study describes bioassay-guided purification and chemotherapeutic evaluation of the 60% ethanolic fraction of P americana organic extracts and the complexity of enriched active fraction was qualitatively evaluated using thin layer chromatography.
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Anticancer agents from marine sponges
TL;DR: This review highlights novel secondary metabolites in sponges which inhibited diverse cancer species in the recent 5 years.
References
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TL;DR: There are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase II/III clinical trials in cancer, analgesia, allergy, and cognitive diseases.
Journal ArticleDOI
Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle.
TL;DR: This review describes the biochemistry of tubulin, microtubules, and the mitotic spindle and describes the natural and synthetic agents which are known to interact with tubulin.