Open AccessJournal Article
Marine natural products as anticancer drugs
TLDR
This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.Abstract:
The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.read more
Citations
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Journal ArticleDOI
Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
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Sponge-Associated Microorganisms: Evolution, Ecology, and Biotechnological Potential
TL;DR: The ecology of sponge-microbe associations is examined, including the establishment and maintenance of these sometimes intimate partnerships, the varied nature of the interactions (ranging from mutualism to host-pathogen relationships), and the broad-scale patterns of symbiont distribution.
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Natural compounds for cancer treatment and prevention
Stefania Nobili,Donatella Lippi,Ewa Witort,Martino Donnini,L Bausi,Enrico Mini,Sergio Capaccioli +6 more
TL;DR: The main natural compounds used in cancer therapy and prevention, the historical aspects of their application and pharmacognosy, and some critical aspects of current cancer chemotherapy are discussed, focusing on genetics and genomics.
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Natural products as leads to anticancer drugs.
TL;DR: Semisynthesis processes of new compounds, obtained by molecular modification of the functional groups of lead compounds, are able to generate structural analogues with greater pharmacological activity and with fewer side effects.
Journal ArticleDOI
Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella.
Eric W. Schmidt,James T. Nelson,David A. Rasko,Sebastian Sudek,Jonathan A. Eisen,Margo G. Haygood,Jacques Ravel +6 more
TL;DR: The full sequencing and functional expression of a marine natural-product pathway from an obligate symbiont is presented, and a related cluster was identified in Trichodesmium erythraeum IMS101, an important bloom-forming cyanobacterium.
References
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Ecteinascidin 743: A Minor Groove Alkylator That Bends DNA toward the Major Groove
TL;DR: Surprisingly, it is found that Et 743 bends DNA toward the major groove, which is a unique feature among DNA-interactive agents that occupy the minor groove.
Journal ArticleDOI
Cyanobacterial symbiont biosynthesis of chlorinated metabolites from Dysidea herbacea (Porifera)
M. D. Unson,D. J. Faulkner +1 more
TL;DR: The flow-cytometric separation of the symbiont from the sponge cells is reported, and it is demonstrated by chemical analyses that a unique group of polychlorinated compounds isolated from the whole sponge tissue is limited to the cyanobacterial filaments, whereas the accompanying sesquiterpenoids are found only in the Sponge cells.
Book ChapterDOI
Nitrogen-containing metabolites from marine cyanobacteria.
TL;DR: The principle biogenetic theme in the natural products chemistry of marine cyanobacteria is the integration of non-ribosomal peptide synthetase and polyketide synthase pathways, in a variety of configurations, so as to produce this great structural diversity.
Journal ArticleDOI
New Marine Derived Anticancer Therapeutics ─ A Journey from the Sea to Clinical Trials
TL;DR: Three innovative compounds with novel mechanisms of action: ET-743, AplidinR and Kahalalide F, have been shown to display a positive therapeutic index and activity in resistant solid tumors that supports the ongoing clinical phase III/II trials.
Journal ArticleDOI
Barbamide, a Chlorinated Metabolite with Molluscicidal Activity from the Caribbean Cyanobacterium Lyngbya majuscula
Jimmy Orjala,William H. Gerwick +1 more
TL;DR: The lipid extract from a Curaçao collection of the marine cyanobacterium Lyngbya majuscula was toxic to the mollusc Biomphalaria glabrata and yielded a novel lipopeptide, barbamide, as the active compound.