Open AccessJournal Article
Marine natural products as anticancer drugs
TLDR
This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.Abstract:
The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.read more
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Senyawa Lipid Spons Haliclona cymaeformis sebagai Biomarka dan Aktivitasnya terhadap Mikroba
TL;DR: Perairan Pulau Talango Madura merupakan habitat bagi berbagai invertebrata laut yang dapat ditemukan dalam hubungan simbiosis dengan makroalga Ceratodictyon spongiosum yang menunjukkan potensi aktivitas inhibitor pertumbuhan mikroba Staphylococcus aureus dan Escherichia coli.
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Phenolic Compounds of Sponge-associated Fungi (Lecanicillium evansii)
TL;DR: In this paper, the secondary metabolites of Lecanicillium evansii were identified using NMR and mass spectrometer analysis, including phenolic compounds (terphenylin, terprenin epoxide), bipeptide (cyclo-tyrosylprolyl), and simple aromatic compounds (acetyl hydroxybenzamide, 4-hydroxybenzaldehyde).
Journal ArticleDOI
Computational Outlook of Marine Compounds as Anti-Cancer Representatives Targeting BCL-2 and Survivin.
Eram Shakeel,Rajnish Kumar,Neha Sharma,Salman Akhtar,Mohd. Kalim Ahmad Khan,Mohtashim Lohani,Mohd. Haris Siddiqui +6 more
TL;DR: These marine derived compounds stimulate apoptosis in cancer cells by targeting Bcl-2 and Survivin, highlighting the fact that instantaneous targeting of these proteins by novel derivatives results in efficacious and selective killing of cancer cells.
Dissertation
Arguments en faveur de l'existence d'une activité pro-apoptotique des lamellarines vis-à-vis des cellules tumorales par ciblage mitochondrial
TL;DR: In this paper, a plupart des traitements anticancereux induisent l'apoptose des cellules tumorales in vitro comme in vivo are discussed.
Journal ArticleDOI
Antiproliferative effects of fresh water crab hemolymph and meat extract on breast cancer cell line
TL;DR: In this article, the authors investigated the effect of freshwater crab hemolymph and meat extract on breast cancer (BC) cell line (4T1) using bicinchoninic acid and cupric reducing antioxidant capacity (CUPRAC) methods.
References
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Journal ArticleDOI
Environmental Genome Shotgun Sequencing of the Sargasso Sea
J. Craig Venter,Karin A. Remington,John F. Heidelberg,Aaron L. Halpern,Doug Rusch,Jonathan A. Eisen,Dongying Wu,Ian T. Paulsen,Karen E. Nelson,William C. Nelson,Derrick E. Fouts,Samuel Levy,Anthony H. Knap,Michael W. Lomas,Kenneth H. Nealson,Owen White,Jeremy Peterson,Jeff Hoffman,Rachel Parsons,Holly Baden-Tillson,Cynthia Pfannkoch,Yu-Hui Rogers,Hamilton O. Smith +22 more
TL;DR: Over 1.2 million previously unknown genes represented in these samples, including more than 782 new rhodopsin-like photoreceptors are identified, suggesting substantial oceanic microbial diversity.
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Natural Products as Sources of New Drugs over the Period 1981−2002
TL;DR: From the data presented, the utility of natural products as sources of novel structures, but not necessarily the final drug entity, is still alive and well, and in the area of cancer, the percentage of small molecule, new chemical entities that are nonsynthetic has remained at 62% averaged over the whole time frame.
Journal ArticleDOI
Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
David J. Newman,Gordon M. Cragg +1 more
TL;DR: There are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase II/III clinical trials in cancer, analgesia, allergy, and cognitive diseases.
Journal ArticleDOI
Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle.
TL;DR: This review describes the biochemistry of tubulin, microtubules, and the mitotic spindle and describes the natural and synthetic agents which are known to interact with tubulin.