Open AccessJournal Article
Marine natural products as anticancer drugs
TLDR
This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.Abstract:
The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.read more
Citations
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Marine Natural Products : A Source of Novel Anticancer Drugs
Shaden A. M. Khalifa,Shaden A. M. Khalifa,Nizar Elias,Mohamed A. Farag,Mohamed A. Farag,Lei Chen,Aamer Saeed,Mohamed-Elamir F. Hegazy,Moustafa Sherief Moustafa,Aida Abd El-Wahed,Saleh Mohammed Al-Mousawi,Syed Ghulam Musharraf,Fang Rong Chang,Arihiro Iwasaki,Kiyotake Suenaga,Muaaz Alajlani,Muaaz Alajlani,Ulf Göransson,Hesham R. El-Seedi +18 more
TL;DR: The impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals, and the possible molecular mechanisms behind the biological effects are presented.
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Rachana Singh,Parul Parihar,Madhulika Singh,Andrzej Bajguz,Jitendra Kumar,Samiksha Singh,Vijay Pratap Singh,Sheo Mohan Prasad +7 more
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Highly efficient cross-dehydrogenative-coupling between ethers and active methylene compounds.
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Bioactive peptides and depsipeptides with anticancer potential: sources from marine animals.
TL;DR: The immense potential of marine animals as bioactive peptide sources, since they have been found as secondary metabolites from sponges, ascidians, tunicates, and mollusks, is demonstrated.
References
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TL;DR: From the data presented, the utility of natural products as sources of novel structures, but not necessarily the final drug entity, is still alive and well, and in the area of cancer, the percentage of small molecule, new chemical entities that are nonsynthetic has remained at 62% averaged over the whole time frame.
Journal ArticleDOI
Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
David J. Newman,Gordon M. Cragg +1 more
TL;DR: There are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase II/III clinical trials in cancer, analgesia, allergy, and cognitive diseases.
Journal ArticleDOI
Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle.
TL;DR: This review describes the biochemistry of tubulin, microtubules, and the mitotic spindle and describes the natural and synthetic agents which are known to interact with tubulin.