Open AccessJournal Article
Marine natural products as anticancer drugs
TLDR
This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.Abstract:
The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.read more
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Biologically active secondary metabolites from Actinomycetes
TL;DR: The diversity of secondary metabolites produced by actinomycete strains with respect to their chemical structure, biological activity and origin is demonstrated and it is concluded that the discovery of new bioactive compounds will continue to pose a great challenge for scientists.
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The stimulating adventure of KRN 7000
Aline Banchet-Cadeddu,Eric Hénon,Manuel Dauchez,Jean-Hugues Renault,Fanny Monneaux,Arnaud Haudrechy +5 more
TL;DR: An up-to-date library of analogues is presented, collecting recent breakthroughs done in crystallography and molecular modelling, and relating them to the available biological results, in order to better understand the recognition and activation mechanisms of immune iNKT cells.
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Molluscan biological and chemical diversity: secondary metabolites and medicinal resources produced by marine molluscs.
TL;DR: This review provides a taxonomic breakdown of the published research on marine molluscan natural products and the medicinal products currently derived frommolluscs, in order to identify priority targets and strategies for future research.
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Anti-inflammatory activity of a sulfated polysaccharide isolated from an enzymatic digest of brown seaweed Sargassum horneri in RAW 264.7 cells
Kalu Kapuge Asanka Sanjeewa,I. P. S. Fernando,Eun A. Kim,Ginnae Ahn,Youngheun Jee,You-Jin Jeon +5 more
TL;DR: The results suggest that CCP has anti-inflammatory activities and is a potential candidate for the formulation of a functional food ingredient or/and drug to treat inflammatory diseases.
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Anticancer alkaloid lamellarins inhibit protein kinases.
Dianne Baunbæk,Nolwenn Trinkler,Yoan Ferandin,Olivier Lozach,Poonsakdi Ploypradith,Somsak Rucirawat,Fumito Ishibashi,Masatomo Iwao,Laurent Meijer +8 more
TL;DR: It is reported that lamellarins inhibit several protein kinases relevant to cancer such as cyclin-dependent kinases, dual-specificity tyrosine phosphorylation activated kinase 1A, casein kinases 1, glycogen synthase kinase-3 and PIM-1.
References
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Environmental Genome Shotgun Sequencing of the Sargasso Sea
J. Craig Venter,Karin A. Remington,John F. Heidelberg,Aaron L. Halpern,Doug Rusch,Jonathan A. Eisen,Dongying Wu,Ian T. Paulsen,Karen E. Nelson,William C. Nelson,Derrick E. Fouts,Samuel Levy,Anthony H. Knap,Michael W. Lomas,Kenneth H. Nealson,Owen White,Jeremy Peterson,Jeff Hoffman,Rachel Parsons,Holly Baden-Tillson,Cynthia Pfannkoch,Yu-Hui Rogers,Hamilton O. Smith +22 more
TL;DR: Over 1.2 million previously unknown genes represented in these samples, including more than 782 new rhodopsin-like photoreceptors are identified, suggesting substantial oceanic microbial diversity.
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Natural Products as Sources of New Drugs over the Period 1981−2002
TL;DR: From the data presented, the utility of natural products as sources of novel structures, but not necessarily the final drug entity, is still alive and well, and in the area of cancer, the percentage of small molecule, new chemical entities that are nonsynthetic has remained at 62% averaged over the whole time frame.
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Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
David J. Newman,Gordon M. Cragg +1 more
TL;DR: There are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase II/III clinical trials in cancer, analgesia, allergy, and cognitive diseases.
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Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle.
TL;DR: This review describes the biochemistry of tubulin, microtubules, and the mitotic spindle and describes the natural and synthetic agents which are known to interact with tubulin.