Open AccessJournal Article
Marine natural products as anticancer drugs
TLDR
This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.Abstract:
The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.read more
Citations
More filters
Journal ArticleDOI
In Vitro Cytotoxic Activity of Isostichopus badionotus, a Sea Cucumber from Yucatan Peninsula Coast
Aida R. Pérez-Espadas,María Julia Verde-Star,Catalina Rivas-Morales,Azucena Oranday-Cárdenas,María Eufemia Morales-Rubio,Lorena V. León-Deniz,Jaqueline Canul-Canche,Leovigildo Quijano +7 more
TL;DR: The in vitro cytotoxic activity of hexane, ethyl acetate and butanol extracts of the sea-cucumber Isostichopus badionotus (Holothuroidea) was tested against normal cells, human cervical carcinoma and breast adenocarcinoma and ATCC cells by 3-(4,5-dimethylthiazol-2-yl)-2-diphenyl tetrazolium bromide (MTT) assay.
Dissertation
Proteomic investigation of an Escherichia coli terpene production factory: prospects for metabolic engineering
TL;DR: This study demonstrates the importance of systems level –omic analyses in shedding light on bottlenecks that prevent commercially viable synthesis of highly beneficial natural products like terpene with E. coli as a biological chassis.
Journal ArticleDOI
Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma
Divya Jain,Yogesh Murti,Wasi Ullah Khan,Rajib Hossain,Mohammad Nabil Hossain,Krishn Kumar Agrawal,Rana Azeem Ashraf,Muhammad Torequl Islam,Pracheta Janmeda,Yasaman Taheri,Mohammed M. Alshehri,Sevgi Durna Daştan,Balakyz Yeskaliyeva,Aliya Kipchakbayeva,Javad Sharifi-Rad,William C. Cho +15 more
TL;DR: In this article, a review on natural bioactive compounds with their effect on hepatocarcinomas is presented, focusing on oxidative stress and FDA-approved signaling pathway inhibitors, along with chemotherapy and radiotherapy enhancers.
Interactive Domains in the Molecular Chaperone Human aB Crystallin Modulate Microtubule Assembly and
TL;DR: These are the first experimental results in support of the functional importance of the dynamic subunit model of small heat shock proteins, which depends on the concentration and ratio of aB crystallin to tubulin.
Journal ArticleDOI
Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug-Resistance Proteins.
Ramesh Dasari,Andrzej Błauż,Derek C. Medellin,Roaa M. Kassim,Carlos Viera,Maximo Santarosa,Alet E. van der Westhuyzen,Willem A. L. van Otterlo,Taryn Olivas,Tugba Yildiz,Tania Betancourt,Charles B. Shuster,Snezna Rogelj,Błażej Rychlik,Todd W. Hudnall,Liliya V. Frolova,Alexander Kornienko +16 more
TL;DR: This work extended the available structure–activity relationship (SAR) data to N3‐ and N9‐substituted derivatives and found that sublines overexpressing ABCG2, ABCC1, and ABCB1 proteins are as responsive to the rigidin analogues as their parental cell lines.
References
More filters
Journal ArticleDOI
Environmental Genome Shotgun Sequencing of the Sargasso Sea
J. Craig Venter,Karin A. Remington,John F. Heidelberg,Aaron L. Halpern,Doug Rusch,Jonathan A. Eisen,Dongying Wu,Ian T. Paulsen,Karen E. Nelson,William C. Nelson,Derrick E. Fouts,Samuel Levy,Anthony H. Knap,Michael W. Lomas,Kenneth H. Nealson,Owen White,Jeremy Peterson,Jeff Hoffman,Rachel Parsons,Holly Baden-Tillson,Cynthia Pfannkoch,Yu-Hui Rogers,Hamilton O. Smith +22 more
TL;DR: Over 1.2 million previously unknown genes represented in these samples, including more than 782 new rhodopsin-like photoreceptors are identified, suggesting substantial oceanic microbial diversity.
Journal ArticleDOI
Natural Products as Sources of New Drugs over the Period 1981−2002
TL;DR: From the data presented, the utility of natural products as sources of novel structures, but not necessarily the final drug entity, is still alive and well, and in the area of cancer, the percentage of small molecule, new chemical entities that are nonsynthetic has remained at 62% averaged over the whole time frame.
Journal ArticleDOI
Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
David J. Newman,Gordon M. Cragg +1 more
TL;DR: There are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase II/III clinical trials in cancer, analgesia, allergy, and cognitive diseases.
Journal ArticleDOI
Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle.
TL;DR: This review describes the biochemistry of tubulin, microtubules, and the mitotic spindle and describes the natural and synthetic agents which are known to interact with tubulin.