Open AccessJournal Article
Marine natural products as anticancer drugs
TLDR
This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.Abstract:
The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.read more
Citations
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Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
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Sponge-Associated Microorganisms: Evolution, Ecology, and Biotechnological Potential
TL;DR: The ecology of sponge-microbe associations is examined, including the establishment and maintenance of these sometimes intimate partnerships, the varied nature of the interactions (ranging from mutualism to host-pathogen relationships), and the broad-scale patterns of symbiont distribution.
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Natural compounds for cancer treatment and prevention
Stefania Nobili,Donatella Lippi,Ewa Witort,Martino Donnini,L Bausi,Enrico Mini,Sergio Capaccioli +6 more
TL;DR: The main natural compounds used in cancer therapy and prevention, the historical aspects of their application and pharmacognosy, and some critical aspects of current cancer chemotherapy are discussed, focusing on genetics and genomics.
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Natural products as leads to anticancer drugs.
TL;DR: Semisynthesis processes of new compounds, obtained by molecular modification of the functional groups of lead compounds, are able to generate structural analogues with greater pharmacological activity and with fewer side effects.
Journal ArticleDOI
Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella.
Eric W. Schmidt,James T. Nelson,David A. Rasko,Sebastian Sudek,Jonathan A. Eisen,Margo G. Haygood,Jacques Ravel +6 more
TL;DR: The full sequencing and functional expression of a marine natural-product pathway from an obligate symbiont is presented, and a related cluster was identified in Trichodesmium erythraeum IMS101, an important bloom-forming cyanobacterium.
References
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Journal ArticleDOI
The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10
George R. Pettit,Yoshiaki Kamano,Cherry L. Herald,Albert A. Tuinman,Fred E. Boettner,Haruhisa Kizu,Jean M. Schmidt,L. Baczynskyj,L. Baczynskyj,Kenneth B. Tomer,Kenneth B. Tomer,Roger J. Bontems +11 more
Journal Article
In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B
Murray J. Towle,Kathleen A. Salvato,Jacqueline Budrow,Bruce F. Wels,Galina Kuznetsov,Kimberley K. Aalfs,Susan Welsh,Wanjun Zheng,Boris M. Seletsky,Monica Palme,Gregory J. Habgood,Lori A. Singer,Lucian Dipietro,Yuan Wang,Jack J. Chen,David A. Quincy,Ashley Davis,Kentaro Yoshimatsu,Yoshito Kishi,Melvin J. Yu,Bruce A. Littlefield +20 more
TL;DR: It is shown that two macrocyclic ketone analogues of halichondrir B, ER-076349 and ER-086526, have sub-nM growth inhibitory activities in vitro against numerous human cancer cell lines as well as marked in vivo activities against four human xenografts.
Journal ArticleDOI
Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata
Kenneth L. Rinehart,Tom G. Holt,N. L. Fregeau,Justin G. Stroh,Paul A. Keifer,Furong Sun,Li H. Li,David G. Martin +7 more
TL;DR: Ecteinascidins 729, 743, 745, 759A,759B, and 770, tris(tetrahydroisoquinolines) with potent in vivo antitumor activity, have been isolated from the colonial tunicate EctEinascidia turbinata, and their structures have been assigned.
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Palytoxin: a new marine toxin from a coelenterate.
Richard E. Moore,Paul J. Scheuer +1 more
TL;DR: Palytoxin has been isolated from the zoanthids "limu-make-o-Hana" (Tentatively identified as Palythoa sp.) as a noncrystalline, chromatographically pure entity and is the most highly toxic substance known.
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Natural products – a simple model to explain chemical diversity
Richard D. Firn,Clive G. Jones +1 more
TL;DR: A simple evolutionary model is presented which explains why organisms produce so many natural products, why so many have low biological activity, why enzymes involved in natural product synthesis have the properties they do and why natural product metabolism is shaped as it is.