Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?

TLDR: Considering their protective action in lesioned sites, MSCs’ secretome might also improve the integration of local progenitor cells in neuroregeneration processes, opening a door for their future use as therapeutic strategies in human clinical trials.

Abstract: The low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have been proposed as a possible therapeutic tool for CNS disorders. In addition to their differentiation potential, it is well accepted nowadays that their beneficial actions can also be mediated by their secretome. Indeed, it was already demonstrated, both in vitro and in vivo, that MSCs are able to secrete a broad range of neuroregulatory factors that promote an increase in neurogenesis, inhibition of apoptosis and glial scar formation, immunomodulation, angiogenesis, neuronal and glial cell survival, as well as relevant neuroprotective actions on different pathophysiological contexts. Considering their protective action in lesioned sites, MSCs’ secretome might also improve the integration of local progenitor cells in neuroregeneration processes, opening a door for their future use as therapeutical strategies in human clinical trials. Thus, in this review we analyze the current understanding of MSCs secretome as a new paradigm for the treatment of CNS neurodegenerative diseases.

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         
         
           
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 

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







         

        




        


       




  

 

      

      


   
        
       

      

 

         





      

      


    

 



 


















         
         
           







     
     
      

  
       
  





     

          


         
         
        








       
       
       

        
      



  








        









      
      


     
  
         







         
       

         
 





         

        


 
        

     


  










         
         
           


    
        
      


     
 



          
 

      
        
      

        
       


      

       

        



        

        






 
     

  
 

     


      
       
      


    
     
      
        
        
         




        

       



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
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         
         
           


    
     




 
       



      

       
      
         
      
    


       
     
       


     



     
      



        

       




        


 
  

 
    





   

       
         
 

     









      



     
     


     


     

       


      

       


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         
         
           




        

       
       
       

         


 
          

      
        
 
        
          

        
      
         
       

        


  



      





      
      

   

       
        



 
       






 




         
         
  

        
         
  
    




Frequently asked questions

Q1. What are the contributions in this paper?

In this paper, the authors proposed a method to identify the root cause of the problem in the first place.