Mesoporous Silica Nanoparticle-Supported Lipid Bilayers (Protocells) for Active Targeting and Delivery to Individual Leukemia Cells.
Paul N. Durfee,Yu Shen Lin,Darren R. Dunphy,Ayse Muniz,Kimberly S. Butler,Kevin R. Humphrey,Amanda J. Lokke,Jacob O. Agola,Stanley S. Chou,I-Ming Chen,Walker Wharton,Jason L. Townson,Cheryl L. Willman,C. Jeffrey Brinker +13 more
TLDR
Overall, the effectiveness of the protocell platform for individual cell targeting and delivery needed for leukemia and other disseminated disease is established.Abstract:
Many nanocarrier cancer therapeutics currently under development, as well as those used in the clinical setting, rely upon the enhanced permeability and retention (EPR) effect to passively accumulate in the tumor microenvironment and kill cancer cells. In leukemia, where leukemogenic stem cells and their progeny circulate within the peripheral blood or bone marrow, the EPR effect may not be operative. Thus, for leukemia therapeutics, it is essential to target and bind individual circulating cells. Here, we investigate mesoporous silica nanoparticle (MSN)-supported lipid bilayers (protocells), an emerging class of nanocarriers, and establish the synthesis conditions and lipid bilayer composition needed to achieve highly monodisperse protocells that remain stable in complex media as assessed in vitro by dynamic light scattering and cryo-electron microscopy and ex ovo by direct imaging within a chick chorioallantoic membrane (CAM) model. We show that for vesicle fusion conditions where the lipid surface area...read more
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Delivering CRISPR: a review of the challenges and approaches.
TL;DR: The focus then turns to the most difficult barrier to potential in vivo use of CRISPR/Cas9, delivery, and detail the various cargos and delivery vehicles reported for CRISpr/ Cas9, including physical delivery vehicles, viral delivery methods, and non-viral delivery methods.
Journal ArticleDOI
Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications.
TL;DR: Trends in the biomedical applications of silica and organosilica nanovectors are delineated, such as unconventional bioimaging techniques, large cargo delivery, combination therapy, gaseous molecule delivery, antimicrobial protection, and Alzheimer's disease therapy.
Journal ArticleDOI
Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer
Anna Watermann,Juergen Brieger +1 more
TL;DR: Mesoporous silica nanoparticles are discussed as biodegradable drug carrier to improve efficacy and reduce side-effects and are a promising tool for innovative, more efficient and safer cancer therapies.
Journal ArticleDOI
In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells
Patrícia Figueiredo,Kalle Lintinen,Alexandros Kiriazis,Ville Hynninen,Zehua Liu,Tomás Bauleth-Ramos,Antti Rahikkala,Alexandra Correia,Tomas Kohout,Bruno Sarmento,Jari Yli-Kauhaluoma,Jouni Hirvonen,Olli Ikkala,Mauri A. Kostiainen,Hélder A. Santos +14 more
TL;DR: In this article, the authors developed three lignin nanoparticles (LNPs): pure LNPs, iron-III-complexed LNNs, and Fe3O4-infused LNN.
Journal ArticleDOI
Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics
Prashant Dogra,Natalie L. Adolphi,Zhihui Wang,Zhihui Wang,Yu Shen Lin,Kimberly S. Butler,Kimberly S. Butler,Paul N. Durfee,Jonas G. Croissant,Achraf Noureddine,Eric N. Coker,Elaine L. Bearer,Vittorio Cristini,Vittorio Cristini,C. Jeffrey Brinker +14 more
TL;DR: It is shown that increased particle size results in a monotonic decrease in systemic bioavailability, irrespective of route of administration, with corresponding accumulation in liver and spleen, and important predictive functional correlations are provided to support the rational design of nanomedicines.
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