Metastasis, an Example of Evolvability.
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In this paper, two different perspectives to analyze the metastatic process taking clear cell renal cell carcinoma as a model, molecular and ecological, were presented, and game theory applied to cell encounters within a tumor provided a sociological perspective of the possible behaviors of individuals in a collectivity.Abstract:
This overview focuses on two different perspectives to analyze the metastatic process taking clear cell renal cell carcinoma as a model, molecular and ecological. On the one hand, genomic analyses have demonstrated up to seven different constrained routes of tumor evolution and two different metastatic patterns. On the other hand, game theory applied to cell encounters within a tumor provides a sociological perspective of the possible behaviors of individuals (cells) in a collectivity. This combined approach provides a more comprehensive understanding of the complex rules governing a neoplasm.read more
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Tumor-to-Tumor Metastases Involving Clear Cell Renal Cell Carcinomas: A Diagnostic Challenge for Pathologists Needing Clinical Correlation
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TL;DR: Remodelling cellular metabolism constitutes a recurrent pattern in ccRCC that correlates with tumour stage and severity and offers new views on the opportunities for disease treatment.
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The evolutionary history of lethal metastatic prostate cancer.
Gunes Gundem,Peter Van Loo,Peter Van Loo,Peter Van Loo,Barbara Kremeyer,Ludmil B. Alexandrov,Jose M. C. Tubio,Elli Papaemmanuil,Daniel Brewer,Heini Kallio,Gunilla Högnäs,Matti Annala,Kati Kivinummi,Victoria Goody,Calli Latimer,Sarah O’Meara,Kevin J. Dawson,William B. Isaacs,Michael R. Emmert-Buck,Matti Nykter,Christopher S. Foster,Zsofia Kote-Jarai,Douglas F. Easton,Hayley C. Whitaker,David E. Neal,Colin Cooper,Colin Cooper,Rosalind A. Eeles,Rosalind A. Eeles,Tapio Visakorpi,Peter J. Campbell,Ultan McDermott,David C. Wedge,G. Steven Bova +33 more
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The seed and soil hypothesis revisited-The role of tumor-stroma interactions in metastasis to different organs
TL;DR: The most frequent target organs of metastasis are bone, brain, liver and the lung, and how tumor‐stromal interactions influence metastasis in each of these organs is discussed.
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Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
Samra Turajlic,Samra Turajlic,Hang Xu,Kevin Litchfield,Andrew Rowan,Tim Chambers,José I. López,David Nicol,Tim O'Brien,James Larkin,Stuart Horswell,Mark Stares,Mark Stares,Lewis Au,Mariam Jamal-Hanjani,Ben Challacombe,Ashish Chandra,Steve Hazell,Claudia Eichler-Jonsson,Aspasia Soultati,Simon Chowdhury,Sarah Rudman,Joanna Lynch,Archana Fernando,Gordon Stamp,Emma Nye,Faiz Jabbar,Lavinia Spain,Sharanpreet Lall,Rosa Guarch,Mary Falzon,Ian Proctor,Lisa Pickering,Martin Gore,Thomas B.K. Watkins,Sophia Ward,Sophia Ward,Aengus Stewart,Renzo G. DiNatale,Maria F. Becerra,Ed Reznik,James J. Hsieh,Todd Richmond,George F. Mayhew,Samantha M. Hill,Catherine D. McNally,Carol Jones,Heidi Rosenbaum,Stacey Stanislaw,Daniel Burgess,Nelson Alexander,Charles Swanton,Charles Swanton +52 more
TL;DR: Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date, and 9p loss is identified as a highly selected event driving metastasis and ccRCC-related mortality.