Book ChapterDOI
microRNA and Allergy.
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TLDR
Among immune system-related microRNAs,miR-21, miR-146a, andMiR-155 are the most intensively studied and have convincingly been demonstrated to regulate immune responses and tissue inflammation in allergic diseases.Abstract:
Allergy is a common hypersensitivity disorder of the immune system, which, along with other factors, is also subjected to regulation by microRNAs. The most common allergic diseases are allergic rhinitis, asthma, atopic dermatitis, and food allergy, which all are multifactorial and very heterogeneous conditions, highlighting the need for more individualized treatment techniques. More particular key questions in relation to allergic diseases are how microRNAs influence the differentiation, polarization, plasticity and functions of T helper and other immune cells, as well as the development of immune tolerance. In addition, microRNAs can affect allergic inflammation and tissue remodeling through their functions in epithelial and other tissue cells. Among immune system-related microRNAs, miR-21, miR-146a, and miR-155 are the most intensively studied and have convincingly been demonstrated to regulate immune responses and tissue inflammation in allergic diseases. Further characterization of microRNA functions is important, as similar to other conditions, the modulation of microRNA expression could potentially be used for therapeutic purposes in allergic diseases in the future. In addition, miRNAs could be implemented as biomarkers for endotyping complex allergic conditions.read more
Citations
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Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis
Lavinia Paternoster,Marie Standl,Chih-Mei Chen,Adaikalavan Ramasamy,Klaus Bønnelykke,Liesbeth Duijts,Manuel A. R. Ferreira,Alexessander Couto Alves,Jacob P. Thyssen,Eva Albrecht,Hansjoerg Baurecht,Hansjoerg Baurecht,Bjarke Feenstra,Patrick M. A. Sleiman,Pirro G. Hysi,Nicole M. Warrington,Ivan Curjuric,Ronny Myhre,John A. Curtin,Maria M. Groen-Blokhuis,Marjan Kerkhof,Annika Sääf,Andre Franke,David Ellinghaus,Regina Foelster-Holst,Emmanouil T. Dermitzakis,Emmanouil T. Dermitzakis,Stephen B. Montgomery,Stephen B. Montgomery,Holger Prokisch,Katharina Heim,Anna-Liisa Hartikainen,Anneli Pouta,Juha Pekkanen,Alexandra I. F. Blakemore,Jessica L. Buxton,Marika Kaakinen,David L. Duffy,Pamela A. F. Madden,Andrew C. Heath,Grant W. Montgomery,Philip J. Thompson,Melanie C. Matheson,Peter N. Le Souëf,Beate St Pourcain,George Davey Smith,John Henderson,John P. Kemp,Nicholas J. Timpson,Panos Deloukas,Susan M. Ring,H-Erich Wichmann,Martina Mueller-Nurasyid,Natalija Novak,Norman Klopp,Elke Rodriguez,Wendy L. McArdle,Allan Linneberg,Torkil Menné,Ellen A. Nohr,Albert Hofman,André G. Uitterlinden,Cornelia M. van Duijin,Fernando Rivadeneira,Johan C. de Jongste,Ralf J. P. van der Valk,Matthias Wjst,Rain Jögi,Frank Geller,Heather A. Boyd,Jeff Murray,Cecilia Kim,Frank D. Mentch,Michael E. March,Massimo Mangino,Tim D. Spector,Veronique Bataille,Craig E. Pennell,Patrick G. Holt,Peter D. Sly,Carla M. T. Tiesler,Elisabeth Thiering,Thomas Illig,Medea Imboden,Medea Imboden,Wenche Nystad,Angela Simpson,Jouke-Jan Hottenga,Dirkje S. Postma,Gerard H. Koppelman,Henriette A. Smit,Cilla Söderhäll,Bo L. Chawes,Eskil Kreiner-Møller,Hans Bisgaard,Erik Melén,Erik Melén,Dorret I. Boomsma,Adnan Custovic,Bo Jacobsson,Bo Jacobsson,Nicole Probst-Hensch,Nicole Probst-Hensch,Lyle J. Palmer,Daniel Glass,Hakon Hakonarson,Hakon Hakonarson,Mads Melbye,Deborah Jarvis,Vincent W. V. Jaddoe,Christian Gieger,David P. Strachan,Nicholas G. Martin,Marjo-Riitta Järvelin,Joachim Heinrich,David M. Evans,Stephan Weidinger +116 more
TL;DR: This paper conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals from 14 studies.
Iconographies supplémentaires de l'article : Inhibition of house dust mite–induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment
TL;DR: The importance of understanding the contribution of miRNAs to pathogenesis of human allergic disease and their potential as novelAnti-inflammatory effects of miR-145 antagonism were comparable to steroid treatment.
Journal ArticleDOI
Epigenetics and allergy: from basic mechanisms to clinical applications
Daniel P. Potaczek,Hani Harb,Hani Harb,Sven Michel,Bilal Alashkar Alhamwe,Harald Renz,Harald Renz,Jörg Tost +7 more
TL;DR: The potential of epigenetic changes for various clinical applications is shown: as diagnostic tools, to assess tolerance following immunotherapy or possibly predict the success of therapy at an early time point and new technological advances such as epigenome editing and DNAzymes will allow targeted alterations of the epigenome in the future and provide novel therapeutic tools.
Journal ArticleDOI
Contribution of MicroRNAs to autoimmune diseases
Lucien P. Garo,Gopal Murugaiyan +1 more
TL;DR: The role of miRNAs in the maintenance of immune tolerance to self-antigens and the gain or loss of miRNA functions on tissue inflammation and autoimmunity is discussed.
Journal ArticleDOI
Spotlight on microRNAs in allergy and asthma.
Julie Weidner,Sabine Bartel,Ayşe Kılıç,Ulrich M. Zissler,Harald Renz,Jürgen Schwarze,Carsten B. Schmidt-Weber,Tania Maes,Ana Rebane,Susanne Krauss-Etschmann,Madeleine Rådinger +10 more
TL;DR: An overview of the current research on miRNAs in allergic diseases, including atopic dermatitis, allergic rhinitis, and asthma is given and how individual miRNas function in the regulation of immune responses in epithelial cells and specialized immune cells in response to different environmental factors and respiratory viruses is discussed.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
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