miR-26a promotes axon regeneration in the mammalian central nervous system by suppressing PTEN expression
Jing Zhang,Yan-Xia Ma,Yu-Qiang Zeng,Shuang-Feng Zhang,Zhao-Qian Teng,Jun Gao,Saijilafu Saijilafu,Chang-Mei Liu +7 more
TLDR
Zhang et al. as discussed by the authors demonstrated that the expression of miR-26a in hippocampal neurons is upregulated developmentally, and they found that overexpression of miRNAs in retinal ganglion cells also promoted the survival and optic nerve regeneration.Abstract:
The permanent disability after the central nervous system (CNS) injury is due to the weakened regeneration ability of the damaged axon, resulting in the loss of the rebuilding functional relationship with the original targets. One determinant of successful axon regeneration is the activation of intrinsic axon growth ability of injured neurons. MicroRNAs are important epigenetic factors controlling axon regeneration. Here, we demonstrated that the expression of miR-26a in hippocampal neurons is upregulated developmentally. Inhibitions of endogenous miR-26a suppressed the axon growth in hippocampal neurons, and overexpression of miR-26a promoted its axon growth. We also found that the overexpression of miR-26a in retinal ganglion cells also promoted retinal ganglion cells’ survival and optic nerve regeneration. Moreover, endogenous miR-26a promotes the hippocampal neuronal axon growth by suppressing phosphatase and tensin homolog deleted on chromosome ten (PTEN) expression. Thus, our results suggested that the miR-26a‒PTEN pathway regulates CNS axon growth. Collectively, the study not only reveals a new mechanism underlying mammalian axon regeneration but also expands the pool of potential targets that can be manipulated to enhance CNS axon regeneration.read more
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Signal Transduction Regulators in Axonal Regeneration
TL;DR: The effects of SPRY and PTEN as well as their regulators in various experimental models of axonal regeneration in vitro and in vivo are focused on.
References
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TL;DR: The manipulation of intrinsic growth control pathways as a therapeutic approach to promote axon regeneration after CNS injury is suggested.
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PTEN deletion enhances the regenerative ability of adult corticospinal neurons
Kai Liu,Yi Lu,Jae K. Lee,Ramsey F. Samara,Rafer Willenberg,Ilse Sears-Kraxberger,Andrea Tedeschi,Kevin K. Park,Duo Jin,Bin Cai,Bengang Xu,Lauren Connolly,Oswald Steward,Binhai Zheng,Zhigang He +14 more
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Klf family members regulate intrinsic axon regeneration ability
TL;DR: In this paper, a method for promoting CNS axon regeneration was proposed, comprising of inhibiting the expression or activity in a neuron of one or more of the members of the Kruppel-like transcription factor (KLF) family that suppress axon growth (e.g., KLF 1, 2, 3, 4, 5, 6, 9, 12, 13, 14, 15 and/or 16), and stimulating the expression and activity of neurons of the KLF family that promote axon expansion.
Journal ArticleDOI
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
Jason T. Huse,Cameron Brennan,Dolores Hambardzumyan,Boyoung Wee,John Pena,Sara H. Rouhanifard,Cherin Sohn-Lee,Carlos le Sage,Reuven Agami,Thomas Tuschl,Eric C. Holland +10 more
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