Mitochondrial Trafficking in Neurons
TLDR
Because the extended axons of neurons contain uniformly polarized microtubules, they have been useful for studying mitochondrial motility in conjunction with biochemical assays in many cell types and can control the clearance and replenishing of mitochondria in the periphery.Abstract:
Neurons, perhaps more than any other cell type, depend on mitochondrial trafficking for their survival. Recent studies have elucidated a motor/adaptor complex on the mitochondrial surface that is shared between neurons and other animal cells. In addition to kinesin and dynein, this complex contains the proteins Miro (also called RhoT1/2) and milton (also called TRAK1/2) and is responsible for much, although not necessarily all, mitochondrial movement. Elucidation of the complex has permitted inroads for understanding how this movement is regulated by a variety of intracellular signals, although many mysteries remain. Regulating mitochondrial movement can match energy demand to energy supply throughout the extraordinary architecture of these cells and can control the clearance and replenishing of mitochondria in the periphery. Because the extended axons of neurons contain uniformly polarized microtubules, they have been useful for studying mitochondrial motility in conjunction with biochemical assays in many cell types.read more
Citations
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The cytoplasmic dynein transport machinery and its many cargoes.
Samara L. Reck-Peterson,William B. Redwine,William B. Redwine,Ronald D. Vale,Andrew P. Carter +4 more
TL;DR: This work focuses on interphase cargoes of dynein, which include membrane-bound organelles, RNAs, protein complexes and viruses, and indicates how adaptor proteins play an important role in this process.
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Bidirectional cargo transport: moving beyond tug of war.
TL;DR: Three classes of bidirectional transport models — microtubule tethering, mechanical activation and steric disinhibition — are proposed, and a general mathematical modelling framework forbidirectional cargo transport is put forward to guide future experiments.
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Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
TL;DR: How stressors influence mitochondria components, and how they contribute to the complex adaptive and pathological responses that lead to disease are discussed.
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Mitochondrial trafficking and anchoring in neurons: New insight and implications
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Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture
TL;DR: Both long-range transport and local processing are at work in achieving neuronal mitostasis-the maintenance of an appropriately distributed pool of healthy mitochondria for the duration of a neuron's life.
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