Monoamine oxidase: from genes to behavior.
Jean C. Shih,K. Chen,M. J. Ridd +2 more
TLDR
MAO A and B knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders and show increased reactivity to stress.Abstract:
Cloning of MAO (monoamine oxidase) A and B has demonstrated unequivocally that these enzymes are made up of different polypeptides, and our understanding of MAO structure, regulation, and function has been significantly advanced by studies using their cDNA. MAO A and B genes are located on the X-chromosome (Xp11.23) and comprise 15 exons with identical intron-exon organization, which suggests that they are derived from the same ancestral gene. MAO A and B knock-out mice exhibit distinct differences in neurotransmitter metabolism and behavior. MAO A knock-out mice have elevated brain levels of serotonin, norephinephrine, and dopamine and manifest aggressive behavior similar to human males with a deletion of MAO A. In contrast, MAO B knock-out mice do not exhibit aggression and only levels of phenylethylamine are increased. Mice lacking MAO B are resistant to the Parkinsongenic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine. Both MAO A and B knock-out mice show increased reactivity to stress. These knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders.read more
Citations
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Basal insulin secretion, PCL-R and recidivism among impulsive violent alcoholic offenders
Kari P. T. Ojala,Jari Tiihonen,Jari Tiihonen,Jari Tiihonen,Eila Repo-Tiihonen,Roope Tikkanen,Matti Virkkunen +6 more
TL;DR: Serum fasting insulin level was equivalent to the PCL-R factor 2 score as a predictor, and better than the total PCL -R score, however, the significance was too low for predicting recidivism in the process of judicial decision-making.
Journal ArticleDOI
Annurca Apple Polyphenol Extract Affects Acetyl- Cholinesterase and Mono-Amine Oxidase In Vitro Enzyme Activity.
Rosarita Nasso,Valentina Pagliara,Stefania D'Angelo,Rosario Rullo,Mariorosario Masullo,Rosaria Arcone +5 more
TL;DR: In this paper, the authors explored the ability of Annurca apple flesh polyphenol extract (AFPE) to affect the activity of key enzymes involved in neurodegenerative disorders-in particular, Acetyl- and Butirryl-cholinesterases, and type A and B monoamine oxidase.
PSYCHIATRIC GENETICS '99 Monoamine Oxidase in Neuropsychiatry and Behavior
J. C. Shih,R. F. Thompson +1 more
TL;DR: Monoamine oxidase catalyzes the oxidative deamination of a number of biogenic amines, including the key neurotransmitters serotonin, norepinephrine, and dopamine and the neuromodulator phenylethylamine.
Journal ArticleDOI
Rapid and sensitive fluorescent probes for monoamine oxidases B to A at low concentrations
TL;DR: These probes have better sensitivity and shorter response time by comparison with similar probes, and have potentials in differentiation of MAO-A andMAO-B upon further optimization.
References
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Some observations upon a new inhibitor of monoamine oxidase in brain tissue.
TL;DR: The hypothesis that in the enzyme prepared, the MAO is a binary system of enzymes each of which has a detectably different sensitivity to this particular inhibitor, is put forward and evidence after dialysis supports this hypothesis.
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Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
TL;DR: Analytical results indicate that isolated complete MAOA deficiency in this family is associated with a recognizable behavioral phenotype that includes disturbed regulation of impulsive aggression.
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Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Olivier Cases,Isabelle Seif,Joseph Grimsby,Patricia Gaspar,Kevin Chen,Sandrine Pournin,Ulrike Müller,Michel Aguet,Charles Babinet,Jean C. Shih,Edward De Maeyer +10 more
TL;DR: Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.