Monoamine oxidase: from genes to behavior.
Jean C. Shih,K. Chen,M. J. Ridd +2 more
TLDR
MAO A and B knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders and show increased reactivity to stress.Abstract:
Cloning of MAO (monoamine oxidase) A and B has demonstrated unequivocally that these enzymes are made up of different polypeptides, and our understanding of MAO structure, regulation, and function has been significantly advanced by studies using their cDNA. MAO A and B genes are located on the X-chromosome (Xp11.23) and comprise 15 exons with identical intron-exon organization, which suggests that they are derived from the same ancestral gene. MAO A and B knock-out mice exhibit distinct differences in neurotransmitter metabolism and behavior. MAO A knock-out mice have elevated brain levels of serotonin, norephinephrine, and dopamine and manifest aggressive behavior similar to human males with a deletion of MAO A. In contrast, MAO B knock-out mice do not exhibit aggression and only levels of phenylethylamine are increased. Mice lacking MAO B are resistant to the Parkinsongenic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine. Both MAO A and B knock-out mice show increased reactivity to stress. These knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders.read more
Citations
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Differential effects of chronic amphetamine and baclofen administration on cAMP levels and phosphorylation of CREB in distinct brain regions of wild type and monoamine oxidase B-deficient mice.
TL;DR: The data reveal that the GABAB‐mediated intracellular signaling differentially participates in mechanisms underlying Amph perturbation to various regions, and may thereby contribute explanations to the behavioral consequences.
Journal ArticleDOI
Monoamine Oxidase A is Required for Rapid Dendritic Remodeling in Response to Stress.
Sean C. Godar,Marco Bortolato,Sarah E Richards,Felix G. Li,Kevin Chen,Cara L. Wellman,Jean C. Shih +6 more
TL;DR: It is suggested that acute stress induces anxiety-like responses by affecting rapid dendritic remodeling in the pyramidal cells of OFC and BLA and that MAO-A and monoamine metabolism are required for these phenomena.
Journal ArticleDOI
Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection.
Miroslava Cuperlovic-Culf,Miroslava Cuperlovic-Culf,Emma L. Cunningham,Hossen Teimoorinia,Anuradha Surendra,Xiaobei Pan,Steffany A. L. Bennett,Mijin Jung,Bernadette McGuiness,Anthony Peter Passmore,David E. Beverland,Brian D. Green +11 more
TL;DR: Analysis of metabolomic profiling of cerebrospinal fluid and blood taken from patients prior to planned orthopaedic surgery found significant concentration 2 differences in several amino acids, acylcarnitines and polyamines linking delirium-prone patients to known factors in Alzheimer’s disease such as monoamine oxidase B (MAOB) protein.
Journal ArticleDOI
Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase.
Xiang Hua Han,Seong Su Hong,Dongho Lee,Jung Joon Lee,Moon Soon Lee,Dong-Cheul Moon,Kun Han,Ki-Wan Oh,Myung Koo Lee,Jai Seup Ro,Bang Yeon Hwang +10 more
TL;DR: The most MAO-B selective compound 5 among the isolates inhibited MAo-B in a competitive manner, according to kinetic analyses by Lineweaver-Burk reciprocal plots.
Journal ArticleDOI
Experimental competition induces immediate and lasting effects on the neurogenome in free-living female birds.
Alexandra B. Bentz,Elizabeth M. George,Sarah E. Wolf,Douglas B. Rusch,Ram Podicheti,Aaron Buechlein,Kenneth P. Nephew,Kimberly A. Rosvall +7 more
TL;DR: In this article, the authors experimentally generated social competition among wild, cavity-nesting female birds (tree swallows, Tachycineta bicolor) and measured transcriptomic and epigenomic responses to competition in two socially relevant brain regions (hypothalamus and ventromedial telencephalon).
References
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Journal ArticleDOI
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Journal ArticleDOI
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
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