Monoamine oxidase: from genes to behavior.
Jean C. Shih,K. Chen,M. J. Ridd +2 more
TLDR
MAO A and B knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders and show increased reactivity to stress.Abstract:
Cloning of MAO (monoamine oxidase) A and B has demonstrated unequivocally that these enzymes are made up of different polypeptides, and our understanding of MAO structure, regulation, and function has been significantly advanced by studies using their cDNA. MAO A and B genes are located on the X-chromosome (Xp11.23) and comprise 15 exons with identical intron-exon organization, which suggests that they are derived from the same ancestral gene. MAO A and B knock-out mice exhibit distinct differences in neurotransmitter metabolism and behavior. MAO A knock-out mice have elevated brain levels of serotonin, norephinephrine, and dopamine and manifest aggressive behavior similar to human males with a deletion of MAO A. In contrast, MAO B knock-out mice do not exhibit aggression and only levels of phenylethylamine are increased. Mice lacking MAO B are resistant to the Parkinsongenic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine. Both MAO A and B knock-out mice show increased reactivity to stress. These knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders.read more
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From the Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
TL;DR: The incidence and some selected risk factors for unprovoked seizures/epilepsy in a large representative population based cohort suggest a possible under-ascertainment in particular among the elderly, and the distribution of cases by gender, seizure type and aetiology indicate that there is no major selection bias.
Journal ArticleDOI
Intermolecular force between monoamine oxidase B and Pseudarthria viscida (L.) using atomic force spectroscopy
Sangami Bharathi Manoharan,Vijayasarathy Marimuthu,Pazhanichamy Kalailingam,Nazeema Banu Basheer,Anandagopu Perumal,Rajendran Kaliaperumal,Kumaran Shanmugam +6 more
TL;DR: This study is perhaps the first report of combining three techniques, namely AFM F–D curves, phytochemical and in silico analysis to measure enzyme–substrate attractive force, constituents of plant extract and position of binding sites, respectively.
Journal ArticleDOI
Interactions of coumarin derivatives with monoamine oxidase biomarkers: In silico approach
TL;DR: In this article , a list of coumarin derivatives (A-P) was investigated for recognizing their reactivity features and their functions towards the monoamine oxidase (MAO) enzyme biomarkers.
Dissertation
Maternal Transfer of Dietary Methylmercury and Implications for Embryotoxicity in Fathead Minnows (Pimephales promelas)
TL;DR: Current exposure scenarios in North American lakes and rivers are sufficient to cause reductions in fitness and survival of early life stage fish, and significantly altered metabolites include those associated with cellular energetics, fatty acid metabolism, and polyamine synthesis are identified.
Monoamine Oxidase in the Regulation of Biopsychological Factors: A Literature Review of the Correlates of Time Perspective, Sensation-Seeking, Boredom Proneness, and Affect
TL;DR: In this article, the authors examined the literature regarding correlates of affect, time perspective, sensation-seeking, and boredom proneness in relation to the activity of specific neurotransmitters, including dopamine and serotonin, and the enzyme monoamine oxidase.
References
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Journal ArticleDOI
Mutation in the α-synuclein gene identified in families with Parkinson's disease
Mihael H. Polymeropoulos,Christian Lavedan,Elisabeth Leroy,Susan E. Ide,Anindya Dehejia,Amalia Dutra,Brian L. Pike,Holly Root,Jeffrey Rubenstein,Rebecca Boyer,Edward S. Stenroos,Settara C. Chandrasekharappa,Aglaia Athanassiadou,Theodore Papapetropoulos,William G. Johnson,Alice Lazzarini,Roger C. Duvoisin,Giuseppe Di Iorio,Lawrence I. Golbe,Robert L. Nussbaum +19 more
TL;DR: A mutation was identified in the α-synuclein gene, which codes for a presynaptic protein thought to be involved in neuronal plasticity, in the Italian kindred and in three unrelated families of Greek origin with autosomal dominant inheritance for the PD phenotype.
Journal ArticleDOI
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study
Mary Sano,Christopher Ernesto,Ronald G. Thomas,Melville R. Klauber,Kimberly Schafer,Michael Grundman,Peter B. Woodbury,John H. Growdon,Carl W. Cotman,Eric Pfeiffer,Lon S. Schneider,Leon J. Thal +11 more
TL;DR: In patients with moderately severe impairment from Alzheimer's disease, treatment with selegiline or alpha-tocopherol slows the progression of disease.
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Some observations upon a new inhibitor of monoamine oxidase in brain tissue.
TL;DR: The hypothesis that in the enzyme prepared, the MAO is a binary system of enzymes each of which has a detectably different sensitivity to this particular inhibitor, is put forward and evidence after dialysis supports this hypothesis.
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Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
TL;DR: Analytical results indicate that isolated complete MAOA deficiency in this family is associated with a recognizable behavioral phenotype that includes disturbed regulation of impulsive aggression.
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Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Olivier Cases,Isabelle Seif,Joseph Grimsby,Patricia Gaspar,Kevin Chen,Sandrine Pournin,Ulrike Müller,Michel Aguet,Charles Babinet,Jean C. Shih,Edward De Maeyer +10 more
TL;DR: Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.