Monoamine oxidase: from genes to behavior.
Jean C. Shih,K. Chen,M. J. Ridd +2 more
TLDR
MAO A and B knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders and show increased reactivity to stress.Abstract:
Cloning of MAO (monoamine oxidase) A and B has demonstrated unequivocally that these enzymes are made up of different polypeptides, and our understanding of MAO structure, regulation, and function has been significantly advanced by studies using their cDNA. MAO A and B genes are located on the X-chromosome (Xp11.23) and comprise 15 exons with identical intron-exon organization, which suggests that they are derived from the same ancestral gene. MAO A and B knock-out mice exhibit distinct differences in neurotransmitter metabolism and behavior. MAO A knock-out mice have elevated brain levels of serotonin, norephinephrine, and dopamine and manifest aggressive behavior similar to human males with a deletion of MAO A. In contrast, MAO B knock-out mice do not exhibit aggression and only levels of phenylethylamine are increased. Mice lacking MAO B are resistant to the Parkinsongenic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine. Both MAO A and B knock-out mice show increased reactivity to stress. These knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders.read more
Citations
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Relationship of monoamine oxidase A binding to adaptive and maladaptive personality traits.
Alexandra Soliman,R. M. Bagby,Alan A. Wilson,Laura Miler,Michael Clark,Pablo Rusjan,Julia Sacher,Sylvain Houle,J Meyer +8 more
TL;DR: A new continuum describing the relationship between personality and MAOA is proposed: deliberate/thoughtful contrasting aggressive/impulsive, and higher MAOA binding is associated with an adaptive personality facet.
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Transcription Factor E2F-Associated Phosphoprotein (EAPP), RAM2/CDCA7L/JPO2 (R1), and Simian Virus 40 Promoter Factor 1 (Sp1) Cooperatively Regulate Glucocorticoid Activation of Monoamine Oxidase B
TL;DR: It is reported that dexamethasone, a synthetic glucocorticoid hormone, stimulates MAO B (an isoform of MAOs) promoter and catalytic activities via both the fourth glucoc Corticoid response element (GRE) and simian virus 40 promoter factor 1 (Sp1) binding sites inMAO B promoter.
Journal ArticleDOI
Division of labor in the honey bee (Apis mellifera) : the role of tyramine β-hydroxylase
Herman K. Lehman,David J. Schulz,Andrew B. Barron,Lydia Wraight,Chris Hardison,Sandra Whitney,Hideaki Takeuchi,Rajib Kumar Paul,Gene E. Robinson +8 more
TL;DR: The results show that the transcription of this neurotransmitter synthetic enzyme is associated with regulation of social behavior in honey bees, but other factors may be involved.
Journal ArticleDOI
Platelet MAO-B, personality, and psychopathology.
TL;DR: It was hypothesized that low platelet MAO-B activity does not directly predispose individuals to psychopathology but is related to specific personality traits, which in turn represent a vulnerability factor for psychopathology.
Journal ArticleDOI
Comparative Neuroprotective Effects of Rasagiline and Aminoindan with Selegiline on Dexamethasone-Induced Brain Cell Apoptosis
Shawna Tazik,Shakevia Johnson,Deyin Lu,Chandra Johnson,Moussa B.H. Youdim,Craig A. Stockmeier,Craig A. Stockmeier,Xiao-Ming Ou +7 more
TL;DR: The greater neuroprotective effect of rasagiline may be associated with the combination of the parent drug and its metabolite, R-aminoindan, with selegiline (Deprenyl) in prevention of dexamethasone-induced brain cell death.
References
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Journal ArticleDOI
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Journal ArticleDOI
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