Monoamine oxidase: from genes to behavior.
Jean C. Shih,K. Chen,M. J. Ridd +2 more
TLDR
MAO A and B knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders and show increased reactivity to stress.Abstract:
Cloning of MAO (monoamine oxidase) A and B has demonstrated unequivocally that these enzymes are made up of different polypeptides, and our understanding of MAO structure, regulation, and function has been significantly advanced by studies using their cDNA. MAO A and B genes are located on the X-chromosome (Xp11.23) and comprise 15 exons with identical intron-exon organization, which suggests that they are derived from the same ancestral gene. MAO A and B knock-out mice exhibit distinct differences in neurotransmitter metabolism and behavior. MAO A knock-out mice have elevated brain levels of serotonin, norephinephrine, and dopamine and manifest aggressive behavior similar to human males with a deletion of MAO A. In contrast, MAO B knock-out mice do not exhibit aggression and only levels of phenylethylamine are increased. Mice lacking MAO B are resistant to the Parkinsongenic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine. Both MAO A and B knock-out mice show increased reactivity to stress. These knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders.read more
Citations
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Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.
Rossella Fioravanti,Adriana Bolasco,Fedele Manna,Francesca Rossi,Francisco Orallo,Matilde Yáñez,Alberto Vitali,Francesco Ortuso,Stefano Alcaro +8 more
TL;DR: Structural-activity relationships and molecular modelling showed that some substitutions, such as benzyloxy or chlorine atom, improve the best interaction with active site of hMAO-B.
Journal ArticleDOI
The Geographic Distribution of Monoamine Oxidase Haplotypes Supports a Bottleneck During the Dispersion of Modern Humans from Africa
TL;DR: A profound change in haplotype frequencies from Africans to non-Africans supports a possible bottleneck during the dispersion of modern humans from Africa.
Journal ArticleDOI
Contribution of Monoamine Oxidase Inhibition to Tobacco Dependence: A Review of the Evidence.
TL;DR: A comprehensive review of the available evidence for the role of MAO inhibition by tobacco-derived substances in tobacco dependence points the way for further research in this field.
Journal ArticleDOI
FlyNap (Triethylamine) Increases the Heart Rate of Mosquitoes and Eliminates the Cardioacceleratory Effect of the Neuropeptide CCAP
Weihan Chen,Julián F. Hillyer +1 more
TL;DR: Exposure to FlyNap eliminated the cardioacceleratory effect of crustacean cardioactive peptide (CCAP), and reduced a mosquito’s ability to survive a bacterial infection, and confirmed that the neurohormone CCAP modulates heart rhythms and that it serves as an anterograde pacemaker.
BookDOI
Patho-epigenetics of disease /
TL;DR: This research attacked the mode of action of EMT using a probabilistic approach, aiming at finding the “spatial checkpoints” within the EMT “cluster”.
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Journal ArticleDOI
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