Monoamine oxidase: from genes to behavior.
Jean C. Shih,K. Chen,M. J. Ridd +2 more
TLDR
MAO A and B knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders and show increased reactivity to stress.Abstract:
Cloning of MAO (monoamine oxidase) A and B has demonstrated unequivocally that these enzymes are made up of different polypeptides, and our understanding of MAO structure, regulation, and function has been significantly advanced by studies using their cDNA. MAO A and B genes are located on the X-chromosome (Xp11.23) and comprise 15 exons with identical intron-exon organization, which suggests that they are derived from the same ancestral gene. MAO A and B knock-out mice exhibit distinct differences in neurotransmitter metabolism and behavior. MAO A knock-out mice have elevated brain levels of serotonin, norephinephrine, and dopamine and manifest aggressive behavior similar to human males with a deletion of MAO A. In contrast, MAO B knock-out mice do not exhibit aggression and only levels of phenylethylamine are increased. Mice lacking MAO B are resistant to the Parkinsongenic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine. Both MAO A and B knock-out mice show increased reactivity to stress. These knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders.read more
Citations
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Enzyme-Activated Fluorogenic Probes for Live-Cell and in Vivo Imaging
Wen Chyan,Ronald T. Raines +1 more
TL;DR: Fluorogenic probes, small-molecule sensors that unmask brilliant fluorescence upon exposure to specific stimuli, are powerful tools for chemical biology and have been widely used for biological imaging as mentioned in this paper.
Journal ArticleDOI
In Vivo and In Vitro Characterization of a Novel MAO-B Inhibitor Radioligand, 18F-Labeled Deuterated Fluorodeprenyl
Sangram Nag,Patrik Fazio,Lutz Lehmann,Georg Kettschau,Tobias Heinrich,Andrea Thiele,Marie Svedberg,Nahid Amini,Samira Leesch,Ana M. Catafau,Jonas Hannestad,Andrea Varrone,Christer Halldin +12 more
TL;DR: The results suggest that 18F-fluorodeprenyl-D2 is a suitable PET radioligand for visualization of MAO-B activity in the human brain.
Journal ArticleDOI
Serotonin, but not dopamine, controls the stress response and anxiety-like behavior in the crayfish Procambarus clarkii
Pascal Fossat,Pascal Fossat,Julien Bacqué-Cazenave,Julien Bacqué-Cazenave,Philippe De Deurwaerdère,Philippe De Deurwaerdère,Daniel Cattaert,Daniel Cattaert,Jean-Paul Delbecque,Jean-Paul Delbecque +9 more
TL;DR: After stress, crayfish brain 5-HT levels increase, which induces anxiety-like behavior (ALB) but the level of dopamine does not change, and in contrast to5-HT, injection of dopaminedoes not trigger a metabolic response or ALB, and this study provides evidence that the anxiogenic effect of 4-HT injections can be prevented by a preliminary injection of 5- HT antagonists.
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Protection of intracellular dopamine cytotoxicity by dopamine disposition and metabolism factors
Paul Weingarten,Qun‐Yong Zhou +1 more
TL;DR: The results support a potential role for non‐oxidative cytoplasmic dopamine toxicity, and imply that disruption in dopamine disposition and/or metabolism could underlie the progressive degeneration of dopaminergic neurons in Parkinson's disease.
Journal ArticleDOI
From gene to aggressive behavior: the role of brain serotonin.
TL;DR: Evidence is provided that brain serotonin makes a significant contribution to the mechanisms underlying genetically determined individual differences in aggressivity, and the genes encoding the main enzymes of serotonin metabolism in the brain and the 5-HT1A receptor are members of a set of genes modulating aggressive behavior.
References
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Some observations upon a new inhibitor of monoamine oxidase in brain tissue.
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Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
TL;DR: Analytical results indicate that isolated complete MAOA deficiency in this family is associated with a recognizable behavioral phenotype that includes disturbed regulation of impulsive aggression.
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Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Olivier Cases,Isabelle Seif,Joseph Grimsby,Patricia Gaspar,Kevin Chen,Sandrine Pournin,Ulrike Müller,Michel Aguet,Charles Babinet,Jean C. Shih,Edward De Maeyer +10 more
TL;DR: Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.