Monoamine oxidase: from genes to behavior.
Jean C. Shih,K. Chen,M. J. Ridd +2 more
TLDR
MAO A and B knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders and show increased reactivity to stress.Abstract:
Cloning of MAO (monoamine oxidase) A and B has demonstrated unequivocally that these enzymes are made up of different polypeptides, and our understanding of MAO structure, regulation, and function has been significantly advanced by studies using their cDNA. MAO A and B genes are located on the X-chromosome (Xp11.23) and comprise 15 exons with identical intron-exon organization, which suggests that they are derived from the same ancestral gene. MAO A and B knock-out mice exhibit distinct differences in neurotransmitter metabolism and behavior. MAO A knock-out mice have elevated brain levels of serotonin, norephinephrine, and dopamine and manifest aggressive behavior similar to human males with a deletion of MAO A. In contrast, MAO B knock-out mice do not exhibit aggression and only levels of phenylethylamine are increased. Mice lacking MAO B are resistant to the Parkinsongenic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine. Both MAO A and B knock-out mice show increased reactivity to stress. These knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders.read more
Citations
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Monoamine oxidases: from tissue homogenates to transgenic mice.
TL;DR: The regulation, structure and function of monoamine oxidases (MAO’s) have been a subject of my research for many years and it is fulfilling and humbling to see how early experiments with tissue homogenates and MAO A andMAO B gene cloning built a foundation for so much subsequent understanding of the molecular and genetic components underlying certain behaviors.
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The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia
Zoran Madzarac,Lucija Tudor,Marina Šagud,Gordana Nedic Erjavec,Alma Mihaljević Peleš,Nela Pivac +5 more
TL;DR: In this paper, the authors found that higher dopamine degradation, associated with COMT and MAO-B genetic variants, is associated with a sex-specific increase in the severity of negative symptoms in schizophrenia patients.
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Low-dose pretreatment with clorgyline decreases the levels of 3-methoxy-4-hydroxyphenylglycol in the striatum and nucleus accumbens and attenuates methamphetamine-induced conditioned place preference in rats.
TL;DR: It is demonstrated that low-dose clorgyline attenuated METH-induced CPP in rats and significantly reduced the tissue levels of monoamines and metabolites examined in the striatum and NAc.
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Discovery of highly selective and potent monoamine oxidase B inhibitors: Contribution of additional phenyl rings introduced into 2-aryl-1,3,4-oxadiazin-5(6H)-one.
Jung Eun Lee,Yeongcheol Lee,So-Jung Park,Joohee Lee,Yeong Shik Kim,Young-Ger Suh,Jeeyeon Lee +6 more
TL;DR: Docking results suggest that an optimal linker between two aromatic rings on the 2-aryl-1,3,4-oxadiazin-5(6H)-one scaffold is a key element in the binding and inhibition of MAO-B.
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Monoamine oxidase A and B activities in embryonic chick hepatocytes: differential regulation by retinoic acid.
TL;DR: It is shown that RA selectively elicits MAO B activity in cultured chick embryonic hepatocytes, this stimulation requires the presence of some factors present in the serum and is probably due to an increase in the number of enzyme molecules.
References
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Journal ArticleDOI
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Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
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