Monoamine oxidase: from genes to behavior.
Jean C. Shih,K. Chen,M. J. Ridd +2 more
TLDR
MAO A and B knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders and show increased reactivity to stress.Abstract:
Cloning of MAO (monoamine oxidase) A and B has demonstrated unequivocally that these enzymes are made up of different polypeptides, and our understanding of MAO structure, regulation, and function has been significantly advanced by studies using their cDNA. MAO A and B genes are located on the X-chromosome (Xp11.23) and comprise 15 exons with identical intron-exon organization, which suggests that they are derived from the same ancestral gene. MAO A and B knock-out mice exhibit distinct differences in neurotransmitter metabolism and behavior. MAO A knock-out mice have elevated brain levels of serotonin, norephinephrine, and dopamine and manifest aggressive behavior similar to human males with a deletion of MAO A. In contrast, MAO B knock-out mice do not exhibit aggression and only levels of phenylethylamine are increased. Mice lacking MAO B are resistant to the Parkinsongenic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine. Both MAO A and B knock-out mice show increased reactivity to stress. These knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders.read more
Citations
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MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1–cMET signaling
Lijuan Yin,Lijuan Yin,Jingjing Li,Jingjing Li,Jing Wang,Tianjie Pu,Jing Wei,Qinlong Li,Boyang Jason Wu +8 more
TL;DR: In this paper, the authors report that monoamine oxidase A (MAOA) is a clinically and functionally important mediator of prostate invasion in PC cells in vitro and tumor innervation in an orthotopic xenograft model.
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The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
Keliang Wang,Keliang Wang,Jie Luo,Shuyuan Yeh,Bosen You,Bosen You,Jialin Meng,Philip Chang,Yuanjie Niu,Gonghui Li,Changxue Lu,Yezi Zhu,Emmanuel S. Antonarakis,Jun Luo,Chi-Ping Huang,Wanhai Xu,Chawnshang Chang,Chawnshang Chang +17 more
TL;DR: Results show that targeting the Enz/ARv7/MAO-A signaling with the antidepressants phenelzine or clorgyline can restore Enz sensitivity to suppress EnzR cell growth, which may indicate that these antidepression drugs can overcome theEnz resistance to further suppress the EnZR CRPC.
Journal ArticleDOI
Monoamine oxidase-A Knockdown in Human Neuroblastoma Cells Reveals Protection Against Mitochondrial Toxins
Julia C. Fitzgerald,Aslihan Ugun-Klusek,George F. G. Allen,Luigi A. De Girolamo,Iain P. Hargreaves,Christoph Ufer,Andrey Y. Abramov,E. Ellen Billett +7 more
TL;DR: Examining how the mitochondrial enzyme monoamine oxidase‐A influences death and survival mechanisms in human neuroblastoma cells revealed protection against mitochondrial toxins, and endogenous MAO‐A levels influence mitochondrial function, notably complex I activity.
Journal Article
Development of Fluorinated Thienylchalcones as Monoamine Oxidase-B Inhibitors: Design, Synthesis, Biological Evaluation and Molecular Docking Studies
Bijo Mathew,Gulberk Ucar,Samiye Yabanogclu-Ciftci,Ipek Baysal,Jerad Suresh,Githa Elizabeth Mathew,Jobin K. Vilapurathu,A. M. Nadeena,P. Nabeela,V. Lakshmi,Abitha Haridas,Fajeelath Fathima +11 more
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Selective blockade of serotonin 5-HT2A receptor increases coronary blood flow via augmented cardiac nitric oxide release through 5-HT1B receptor in hypoperfused canine hearts
Masashi Fujita,Tetsuo Minamino,Shoji Sanada,Hiroshi Asanuma,Akio Hirata,Hisakazu Ogita,Ken-ichiro Okada,Osamu Tsukamoto,Seiji Takashima,Hitonobu Tomoike,Koichi Node,Masatsugu Hori,Masafumi Kitakaze +12 more
TL;DR: Immunohistochemical analysis showed that sarpogrelate induced serotonin production in ischemic cardiac myocytes and suggested that the increase in cardiac release of serotonin may increase NO production in the isChemic heart.
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Journal ArticleDOI
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Journal ArticleDOI
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