Monoamine oxidase: from genes to behavior.
Jean C. Shih,K. Chen,M. J. Ridd +2 more
TLDR
MAO A and B knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders and show increased reactivity to stress.Abstract:
Cloning of MAO (monoamine oxidase) A and B has demonstrated unequivocally that these enzymes are made up of different polypeptides, and our understanding of MAO structure, regulation, and function has been significantly advanced by studies using their cDNA. MAO A and B genes are located on the X-chromosome (Xp11.23) and comprise 15 exons with identical intron-exon organization, which suggests that they are derived from the same ancestral gene. MAO A and B knock-out mice exhibit distinct differences in neurotransmitter metabolism and behavior. MAO A knock-out mice have elevated brain levels of serotonin, norephinephrine, and dopamine and manifest aggressive behavior similar to human males with a deletion of MAO A. In contrast, MAO B knock-out mice do not exhibit aggression and only levels of phenylethylamine are increased. Mice lacking MAO B are resistant to the Parkinsongenic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine. Both MAO A and B knock-out mice show increased reactivity to stress. These knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders.read more
Citations
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Journal ArticleDOI
A unique demographic history exists for the MAO-A gene in Polynesians.
TL;DR: A unique demographic history exists at the MAO-A gene in the Maori population and points toward a 5-SNP haplotype that may have been influenced by selective effects in theMaori population.
Dissertation
Monoamine Oxidase-A in Borderline Personality Disorder and Antisocial Personality Disorder
TL;DR: In this article, the authors used harmine positron emission tomography (PET) to assess the MAO-A total distribution volume (MAO) in females with Borderline personality disorder and antisocial personality disorder (ASPD).
Dissertation
Estudio genético en esquizofrenia: análisis de variantes funcionales para la identificación de factores de predisposición
TL;DR: In this article, the authors identify variantes of susceptibilidad a esquizofrenia, tanto comunes como raras, in genes candidato de vulnerabilidad a trastornos psiquiatricos.
Journal ArticleDOI
Cerebral MAO Activity Is Not Altered by a Novel Herbal Antidepressant Treatment.
Ravid Doron,Ziv Versano,Or Burstein,Motty Franko,Alon Shamir,Roni Toledano,Assaf Handelsman,Moshe Rehavi +7 more
TL;DR: Treatment with NHT was supported as safe in terms of risk for inducing a hypertensive response and the antidepressant- and anxiolytic-like effects of NHT are mediated via pathways other than MAO-A/B inhibition.
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Journal ArticleDOI
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Journal ArticleDOI
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
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TL;DR: Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.