mTORC1 Links Protein Quality and Quantity Control by Sensing Chaperone Availability
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TLDR
It is demonstrated that cells distinguish moderate reductions in protein quality from severe protein misfolding using molecular chaperones to differentially regulate mTORC1 signaling, and the tight linkage between protein quality and quantity control provides a plausible mechanism coupling protein mis folding with metabolic dyshomeostasis.About:
This article is published in Journal of Biological Chemistry.The article was published on 2010-08-27 and is currently open access. It has received 50 citations till now. The article focuses on the topics: Hsp33 & Chaperone (protein).read more
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Seven sirtuins for seven deadly diseases ofaging
TL;DR: Since sirtuins are crucial to pathways that counter the decline in health that accompanies aging, pharmacological agents that boost sirtuin activity have clinical potential in treatment of diabetes, cardiovascular disease, dementia, osteoporosis, arthritis, and other conditions.
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Cellular stress response pathways and ageing: intricate molecular relationships
TL;DR: The molecular mechanisms that link ageing to main stress response pathways are surveyed, and how each pathway contributes to modulate the ageing process is discussed.
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Cotranslational Response to Proteotoxic Stress by Elongation Pausing of Ribosomes
TL;DR: It is reported that intracellular proteotoxic stress reduces global protein synthesis by halting ribosomes on transcripts during elongation, suggesting a dual role of molecular chaperones in facilitating polypeptide elongation and cotranslational folding.
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The Stress of Protein Misfolding: From Single Cells to Multicellular Organisms
TL;DR: This work will address how protein homeostasis (proteostasis) is achieved at the level of the cell and organism, and how the threshold of the stress response is set to detect and combat protein misfolding.
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Degradation of the Endoplasmic Reticulum by Autophagy during Endoplasmic Reticulum Stress in Arabidopsis
TL;DR: It is suggested that autophagy serves as a pathway for the turnover of ER membrane and its contents in response to ER stress in plants.
References
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Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
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Folding of Newly Translated Proteins In Vivo: The Role of Molecular Chaperones
TL;DR: Genetic and biochemical analysis shows that several distinct chaperone systems, including Hsp70 and the cylindrical chaperonins, assist the folding of proteins upon translation in the cytosol of both prokaryotic and eukaryotic cells.
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Genetics: Influence of TOR kinase on lifespan in C. elegans
TL;DR: It is shown that TOR deficiency in the nematode Caenorhabditis elegans more than doubles its natural lifespan, suggesting a new function for TOR signalling in ageing control may represent a link between nutrition, metabolism and longevity.
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Dysregulation of the TSC-mTOR pathway in human disease.
TL;DR: Emerging evidence for a functional relationship between the mTOR signaling pathway and several genetic diseases is discussed, and evidence supporting a model in which dysregulation of mTOR may be a common molecular basis for hamartoma syndromes and for other cellular hypertrophic disorders is presented.
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Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
TL;DR: The consequences of an imbalance in homeostasis on the flux of misfolded proteins that, if unattended, can result in severe molecular damage to the cell are examined.