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Open AccessJournal ArticleDOI

Next Generation of Computationally Optimized Broadly Reactive HA Vaccines Elicited Cross-Reactive Immune Responses and Provided Protection against H1N1 Virus Infection

Ying Huang, +4 more
- 16 Jul 2021 - 
- Vol. 9, Iss: 7, pp 793
TLDR
In order to conquer the antigenic variability and improve influenza virus vaccine efficacy, this paper developed computationally optimized broadly reactive antigens (COBRAs) in the form of recombinant hemagglutinins (rHAs) to elicit broader immune responses.
About: 
This article is published in Vaccine.The article was published on 2021-07-16 and is currently open access. It has received 14 citations till now. The article focuses on the topics: Vaccination & Cobra.

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SARS-CoV-2 and Influenza A Virus Coinfections in Ferrets

- 09 Mar 2022 - 
TL;DR: In this paper , the authors examined the effect of coinfection ferret models described in this paper on the ability to prevent the most severe effects of viral coinfections and found that vaccination significantly ameliorated influenza-associated disease by protecting vaccinated animals from severe morbidity after IAV single infection or IAV and SARS-CoV-2 coinfectation.
Journal ArticleDOI

Bivalent H1 and H3 COBRA Recombinant Hemagglutinin Vaccines Elicit Seroprotective Antibodies against H1N1 and H3N2 Influenza Viruses from 2009 to 2019

James D. Allen, +1 more
- 15 Mar 2022 - 
TL;DR: Overall, the newly generated COBRA HA antigens had the ability to induce broadly reactive antibodies in influenza-naive and preimmune animals in both monovalent and bivalent formulations, and these antIGens outperformed H1 and H3 WT rHA vaccine antigen by eliciting seroprotective antibodies against panels of antigenically drifted historical H1N1 andH3N2 vaccine strains from 2009 to 2019.
Journal ArticleDOI

Development of an Intranasal Gel for the Delivery of a Broadly Acting Subunit Influenza Vaccine.

Devika M. Varma, +12 more
- 30 Mar 2022 - 
TL;DR: Overall, this study indicates the utility of an intranasal gel for the delivery of COBRAs for the generation of serum and mucosal humoral responses.
Journal ArticleDOI

Progress towards the Development of a Universal Influenza Vaccine

Wen-Chien Wang, +3 more
- 30 Jul 2022 - 
TL;DR: This review provides the latest progress in the development of universal influenza vaccines and identifies several innovative strategies and vaccine platforms being explored to generate robust cross-protective immunity.
Journal ArticleDOI

Multiplexed Electrospray Enables High Throughput Production of cGAMP Microparticles to Serve as an Adjuvant for a Broadly Acting Influenza Vaccine.

Cole J. Batty, +5 more
- 01 May 2022 - 
TL;DR: In this paper , the stimulator of interferon genes (STING) agonist cyclic dinucleotide 3'3'-cyclic guanosine monophosphate-adenosine monosphate (cGAMP) was encapsulated in acetalated dextran (Ace-DEX) microparticles through electrospray.
References
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Journal ArticleDOI

Evolution and ecology of influenza A viruses.

Robert G. Webster, +4 more
- 01 Mar 1992 - 
TL;DR: Wild aquatic bird populations have long been considered the natural reservoir for influenza A viruses with virus transmission from these birds seeding other avian and mammalian hosts, but recent studies in bats have suggested other reservoir species may also exist.
Journal ArticleDOI

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study

A. Danielle Iuliano, +138 more
- 13 Dec 2017 - 
TL;DR: These global influenza-associated respiratory mortality estimates are higher than previously reported, suggesting that previous estimates might have underestimated disease burden.
Journal ArticleDOI

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

David J. DiLillo, +3 more
- 01 Feb 2014 - 
TL;DR: DiLillo et al. as mentioned in this paper showed that anti-stalk mAbs can mediate antibody-dependent cell cytotoxicity and require interactions with Fc receptors for their in vivo neutralizing activity.
Journal ArticleDOI

The quantitative determination of influenza virus and antibodies by means of red cell agglutination.

George K. Hirst
- 01 Jan 1942 - 
TL;DR: The agglutination titer for chicken red cells of freshly prepared or carefully stored suspensions of PR8 influenza virus, that is to say virus of maximum pathogenicity, was found to be proportional to the mouse lethal titer of the same preparations.
Journal ArticleDOI

Variable influenza vaccine effectiveness by subtype: a systematic review and meta-analysis of test-negative design studies

Edward A. Belongia, +6 more
- 01 Aug 2016 - 
TL;DR: A systematic review and meta-analysis of Influenza vaccine effectiveness (VE) found vaccines provided substantial protection against H1N1pdm09, H1n1 (pre-2009), and type B, and reduced Protection against H3N2.
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